Wie Designer-Rekombinasen Erbkrankheiten heilen könnten
Research output: Contribution to journal › Research article › Invited
Contributors
Abstract
Recent advances in nuclease-based genome editing allow for the correction of many point-mutations causing diseases. However, correcting genetic alterations caused by larger chromosomal rearrangements remain challenging with this approach. Designer-recombinases promise to fill this gap as demonstrated by the development of a heterodimeric Cre-based site-specific recombinase system. This system can functionally correct a large gene inversion frequently found in patients with severe Hemophilia A.
Details
Original language | German |
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Journal | Biospektrum |
Volume | 27 |
Publication status | Published - Mar 2021 |
Peer-reviewed | No |
External IDs
Scopus | 85103171326 |
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