The invention relates to a two-wheeled vehicle frame with two frame half-shells (1, 1′) which are joined so as to form a support frame (3), thereby forming at least one inner cavity (2). The support frame (3) has at least one separating surface (4) on which the two frame half-shells (1, 1′) rest against each other. The support frame (3) preferably has receiving areas (5, 6, 7) for a handlebar tube and/or a bottom bracket and/or an operator seat tube. The support frame (3) forms a rear structure (8) for assembling a rear wheel (9) at the rear end when seen in the travel direction (z). In order to form the rear structure (8), a left-hand support brace (10) when seen in the travel direction (z) and a right-hand support brace (11) when seen in the travel direction (z) are provided such that the rear wheel (8) can be mounted between the two support braces (10, 11). According to the invention, the separating surface (4) runs between the two frame half-shells (1, 1′) as well as through the left-hand support brace (10) and through the right-hand support brace (11).