The Rad52 SSAP superfamily and new insight into homologous recombination
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures, now put the issue beyond doubt.
Details
Original language | English |
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Article number | 87 |
Number of pages | 4 |
Journal | Communications biology |
Volume | 6 |
Issue number | 1 |
Publication status | Published - 23 Jan 2023 |
Peer-reviewed | Yes |
External IDs
PubMedCentral | PMC9870868 |
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Scopus | 85146769089 |
ORCID | /0000-0003-2848-6949/work/141543415 |
ORCID | /0000-0002-4754-1707/work/142248115 |
Keywords
Keywords
- Homologous Recombination, Rad52 DNA Repair and Recombination Protein/genetics