The Rad52 SSAP superfamily and new insight into homologous recombination

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures, now put the issue beyond doubt.

Details

Original languageEnglish
Article number87
Number of pages4
JournalCommunications biology
Volume6
Issue number1
Publication statusPublished - 23 Jan 2023
Peer-reviewedYes

External IDs

PubMedCentral PMC9870868
Scopus 85146769089
ORCID /0000-0003-2848-6949/work/141543415
ORCID /0000-0002-4754-1707/work/142248115

Keywords

Keywords

  • Homologous Recombination, Rad52 DNA Repair and Recombination Protein/genetics

Library keywords