Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures, now put the issue beyond doubt.
|Number of pages||4|
|Publication status||Published - 23 Jan 2023|
- Homologous Recombination, Rad52 DNA Repair and Recombination Protein/genetics