The Rad52 SSAP superfamily and new insight into homologous recombination

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Abstract

Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures, now put the issue beyond doubt.

Details

OriginalspracheEnglisch
Aufsatznummer87
Seitenumfang4
FachzeitschriftCommunications biology
Jahrgang6
Ausgabenummer1
PublikationsstatusVeröffentlicht - 23 Jan. 2023
Peer-Review-StatusJa

Externe IDs

PubMedCentral PMC9870868
Scopus 85146769089
ORCID /0000-0003-2848-6949/work/141543415
ORCID /0000-0002-4754-1707/work/142248115

Schlagworte

Schlagwörter

  • Homologous Recombination, Rad52 DNA Repair and Recombination Protein/genetics

Bibliotheksschlagworte