Spider Chitin. The biomimetic potential and applications of Caribena versicolor tubular chitin

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Tomasz Machałowski - , Poznań University of Technology (Author)
  • Marcin Wysokowski - , Poznań University of Technology, Freiberg University of Mining and Technology (Author)
  • Sonia Żółtowska-Aksamitowska - , Poznań University of Technology, Freiberg University of Mining and Technology (Author)
  • Nicole Bechmann - , Institute of Clinical Chemistry and Laboratory Medicine, TUD Dresden University of Technology (Author)
  • Björn Binnewerg - , Institute of Pharmacology and Toxicology, TUD Dresden University of Technology (Author)
  • Mario Schubert - , Institute of Pharmacology and Toxicology, TUD Dresden University of Technology (Author)
  • Kaomei Guan - , Institute of Pharmacology and Toxicology, TUD Dresden University of Technology (Author)
  • Stefan R. Bornstein - , Department of internal Medicine 3, TUD Dresden University of Technology (Author)
  • Katarzyna Czaczyk - , Poznań University of Life Sciences (Author)
  • Oleg Pokrovsky - , Géosciences Environment Toulouse (GET), Tomsk State University (Author)
  • Michael Kraft - , Freiberg University of Mining and Technology (Author)
  • Martin Bertau - , Freiberg University of Mining and Technology (Author)
  • Christian Schimpf - , Freiberg University of Mining and Technology (Author)
  • David Rafaja - , Freiberg University of Mining and Technology (Author)
  • Mikhail Tsurkan - , Chair of Cell Replacement in the Mammalian Retina, Leibniz Institute of Polymer Research Dresden (Author)
  • Roberta Galli - , Clinical Sensoring and Monitoring, Department of Medical Physics and Biomedical Engineering, TUD Dresden University of Technology (Author)
  • Heike Meissner - , Department of Prosthodontics, Department of Prosthetic Dentistry, TUD Dresden University of Technology (Author)
  • Iaroslav Petrenko - , Freiberg University of Mining and Technology (Author)
  • Andriy Fursov - , Freiberg University of Mining and Technology (Author)
  • Alona Voronkina - , National Pirogov Memorial Medical University, Vinnytsya (Author)
  • Marek Figlerowicz - , Polish Academy of Sciences (Author)
  • Yvonne Joseph - , Freiberg University of Mining and Technology (Author)
  • Teofil Jesionowski - , Poznań University of Technology (Author)
  • Hermann Ehrlich - , Freiberg University of Mining and Technology (Author)

Abstract

Diverse fields of modern technology and biomedicine can benefit from the application of ready-to-use chitin-based scaffolds. In this work we show for the first time the applicability of tubular and porous chitin from Caribena versicolor spiders as a scaffold for the development of an effective CuO/Cu(OH)2 catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AM), and as a scaffold for the tissue engineering of selected cells. The formation of CuO/Cu(OH)2 phases on and within the chitinous tubes leads to a hybrid material with excellent catalytic performance with respect to the reduction of p-nitrophenol. On the other hand, experimental results provide for the first time strong evidence for the biocompatibility of spider chitin with different cell types, a human progenitor cell line (hPheo1), as well as cardiomyocytes differentiated from induced pluripotent stem cells (iPSC-CMs) that were cultured on a tube-like scaffold.

Details

Original languageEnglish
Article number115301
JournalCarbohydrate polymers
Volume226
Publication statusPublished - 15 Dec 2019
Peer-reviewedYes

External IDs

PubMed 31582063
ORCID /0000-0002-0633-0321/work/141544790
ORCID /0000-0002-8375-8233/work/142236385
ORCID /0000-0002-6932-333X/work/142239659

Keywords

Keywords

  • biocompatibility, biopolymers, catalyst, chitin, human cells, spider molt cuticle, tissue engineering