Exceptionally versatile take II: Post-Translational modifications of lysine and their impact on bacterial physiology

Research output: Contribution to journalReview articleContributedpeer-review


  • Jürgen Lassak - , Ludwig Maximilian University of Munich (Author)
  • Alina Sieber - , Ludwig Maximilian University of Munich (Author)
  • Michael Hellwig - , Chair of Special Food Chemistry, Institute of Food Chemistry, Technical University of Braunschweig (Author)


Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical diversity of post-Translational modifications. This results in a wide range of possibilities to influence protein function and hence modulate cellular physiology. Concomitantly, lysine derivatives form a metabolic reservoir that can confer selective advantages to those organisms that can utilize it. In this review, we provide examples of selected lysine modifications and describe their role in bacterial physiology.


Original languageEnglish
Pages (from-to)819-858
Number of pages40
Journal Biological chemistry
Issue number8-9
Publication statusPublished - 17 Feb 2022

External IDs

PubMed 35172419
unpaywall 10.1515/hsz-2021-0382
Mendeley fa735682-e71c-34ae-b05d-28e0ae4060a2



  • acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism