Exceptionally versatile take II: Post-Translational modifications of lysine and their impact on bacterial physiology

Research output: Contribution to journal › Review article › Contributed › peer-review

Contributors

  • Jürgen Lassak - , Ludwig Maximilian University of Munich (Author)
  • Alina Sieber - , Ludwig Maximilian University of Munich (Author)
  • Michael Hellwig - , Technical University of Braunschweig (Author)

Abstract

Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical diversity of post-Translational modifications. This results in a wide range of possibilities to influence protein function and hence modulate cellular physiology. Concomitantly, lysine derivatives form a metabolic reservoir that can confer selective advantages to those organisms that can utilize it. In this review, we provide examples of selected lysine modifications and describe their role in bacterial physiology.

Details

Original languageEnglish
Pages (from-to)819-858
Number of pages40
Journal Biological chemistry
Volume403
Issue number8-9
Early online date17 Feb 2022
Publication statusPublished - 26 Jul 2022
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 35172419
unpaywall 10.1515/hsz-2021-0382
Mendeley fa735682-e71c-34ae-b05d-28e0ae4060a2
ORCID /0000-0001-8528-6893/work/142256519

Keywords

ASJC Scopus subject areas

Keywords

  • acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism

Library keywords