Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical diversity of post-Translational modifications. This results in a wide range of possibilities to influence protein function and hence modulate cellular physiology. Concomitantly, lysine derivatives form a metabolic reservoir that can confer selective advantages to those organisms that can utilize it. In this review, we provide examples of selected lysine modifications and describe their role in bacterial physiology.
|Number of pages||40|
|Publication status||Published - 17 Feb 2022|
- acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism