Exceptionally versatile take II: Post-Translational modifications of lysine and their impact on bacterial physiology

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel (Review) › Beigetragen › Begutachtung

Beitragende

  • Jürgen Lassak - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Alina Sieber - , Ludwig-Maximilians-Universität München (LMU) (Autor:in)
  • Michael Hellwig - , Technische Universität Braunschweig (Autor:in)

Abstract

Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical diversity of post-Translational modifications. This results in a wide range of possibilities to influence protein function and hence modulate cellular physiology. Concomitantly, lysine derivatives form a metabolic reservoir that can confer selective advantages to those organisms that can utilize it. In this review, we provide examples of selected lysine modifications and describe their role in bacterial physiology.

Details

OriginalspracheEnglisch
Seiten (von - bis)819-858
Seitenumfang40
Fachzeitschrift Biological chemistry
Jahrgang403
Ausgabenummer8-9
Frühes Online-Datum17 Feb. 2022
PublikationsstatusVeröffentlicht - 26 Juli 2022
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 35172419
unpaywall 10.1515/hsz-2021-0382
Mendeley fa735682-e71c-34ae-b05d-28e0ae4060a2
ORCID /0000-0001-8528-6893/work/142256519

Schlagworte

ASJC Scopus Sachgebiete

  • Molekularbiologie - acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism
  • Biochemie - acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism
  • Klinische Biochemie - acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism

Schlagwörter

  • acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism

Bibliotheksschlagworte

  • 540 Chemie und zugeordnete Wissenschaften - acylation, EF-P modifications, glycation, methylation, oxidation, pupylation, Proteins/metabolism, Lysine/metabolism, Bacterial Physiological Phenomena, Protein Processing, Post-Translational, Amino Acids/metabolism