Employment of the covariance matrix in parameter estimation for stochastic processes in cell biology

Research output: Contribution to book/Conference proceedings/Anthology/ReportConference contributionContributedpeer-review

Contributors

  • Roland Preuss - , Max Planck Institute for Plasma Physics (Author)
  • P. Dieterich - , Institute of Physiology (Author)

Abstract

The dynamics of movements of biological cells can be described with models from correlated stochastic processes. In order to overcome problems from correlated and insufficient data in the determination of the model parameters of such processes we employ the covariance matrix of the data. Since the covariance suffers itself from statistical uncertainty it is corrected by a renormalization treatment [1]. For the example of normal and fractional Brownian motion, which allows both to access all quantities on full theoretical grounds and to generate data similar to experiment, we discuss our results and those of previous works by Gregory [2] and Sivia [3]. The presented approach has the potential to estimate the aging correlation function of observed cell paths and can be applied to more complicated models.

Details

Original languageEnglish
Title of host publicationBayesian Inference and Maximum Entropy Methods in Science and Engineering - 32nd International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering
Pages114-121
Number of pages8
Publication statusPublished - 2013
Peer-reviewedYes

Publication series

SeriesAIP Conference Proceedings
Volume1553
ISSN0094-243X

Conference

Title32nd International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering, MaxEnt 2012
Duration15 - 20 July 2012
CityGarching
CountryGermany

External IDs

ORCID /0000-0002-3564-0193/work/175220764

Keywords

ASJC Scopus subject areas