Biosensor for calcium based on a hydrogel optical waveguide with integrated sensor proteins
Research output: Contribution to book/conference proceedings/anthology/report › Conference contribution › Contributed › peer-review
Contributors
Abstract
We present a new optical biosensor concept based on hydrogel waveguides with integrated fluorescent proteins developed as a platform for implantable sensors. In this prototype the sensor detects the presence or absence of calcium through changes in fluorescence resonance energy transfer (FRET) induced by conformational changes of a FRET protein. The protein is immobilized in a synthetic hydrogel matrix with cylindrical shape, which serves simultaneously as an optical waveguide for the excitation light. The specificity of the protein determines which molecule can be detected.
Details
Original language | German |
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Title of host publication | TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference |
Publisher | IEEE |
Pages | 1218-1221 |
Number of pages | 4 |
ISBN (print) | 978-1-4244-4193-8 |
Publication status | Published - 25 Jun 2009 |
Peer-reviewed | Yes |
Conference
Title | TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference |
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Duration | 21 - 25 June 2009 |
Location | Denver, CO, USA |
External IDs
Scopus | 71449114994 |
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ORCID | /0000-0002-0757-3325/work/139064831 |
Keywords
Keywords
- Biosensors, Optical sensors, Optical waveguides, Calcium, Biomedical optical imaging, Integrated optics, Fluorescence, Protein engineering, Prototypes, Resonance