Biosensor for calcium based on a hydrogel optical waveguide with integrated sensor proteins
Publikation: Beitrag in Buch/Konferenzbericht/Sammelband/Gutachten › Beitrag in Konferenzband › Beigetragen › Begutachtung
Beitragende
Abstract
We present a new optical biosensor concept based on hydrogel waveguides with integrated fluorescent proteins developed as a platform for implantable sensors. In this prototype the sensor detects the presence or absence of calcium through changes in fluorescence resonance energy transfer (FRET) induced by conformational changes of a FRET protein. The protein is immobilized in a synthetic hydrogel matrix with cylindrical shape, which serves simultaneously as an optical waveguide for the excitation light. The specificity of the protein determines which molecule can be detected.
Details
Originalsprache | Deutsch |
---|---|
Titel | TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference |
Herausgeber (Verlag) | IEEE |
Seiten | 1218-1221 |
Seitenumfang | 4 |
ISBN (Print) | 978-1-4244-4193-8 |
Publikationsstatus | Veröffentlicht - 25 Juni 2009 |
Peer-Review-Status | Ja |
Konferenz
Titel | TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference |
---|---|
Dauer | 21 - 25 Juni 2009 |
Ort | Denver, CO, USA |
Externe IDs
Scopus | 71449114994 |
---|---|
ORCID | /0000-0002-0757-3325/work/139064831 |
Schlagworte
Schlagwörter
- Biosensors, Optical sensors, Optical waveguides, Calcium, Biomedical optical imaging, Integrated optics, Fluorescence, Protein engineering, Prototypes, Resonance