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University Cancer Centre Dresden, Medical Systems Biology

Organisational unit: Chair

Organisation profile

Systems biology and genome engineering are at the forefront of transforming our healthcare system. The Department of Medical Systems Biology at the University Cancer Center of TU Dresden integrates functional genomics, high-throughput biology and genome editing to transform precision medicine.

Contact

Type of address: Visiting Adress.

BIOTEC
Medical Systems Biology, Prof. Dr. Frank Buchholz
Tatzberg 47/49
01307 Dresden

Germany

Type of address: Postal address.

UCC, Medical Systems Biology
Prof. Dr. Frank Buchholz
Medizinische Fakultät, TU Dresden
Fetscherstr. 74
01307 Dresden

Germany

Phone: 0351-46340274

Email: buchholz-office@groups.tu-dresden.de

Other website: http://www.buchholzlab.org/
TUD website: https://tu-dresden.de/med/mf/ucc/medsys?set_language=en

Parent units

University Cancer Centre Dresden

Related content and researchers (public profile)

Research output
Journals
Activities
Prizes
Press/Media

Methylstat sensitizes ovarian cancer cells to PARP-inhibition by targeting the histone demethylases JMJD1B/C

Schwarz, F. M., Klotz, D. M., Yang, R., Brux, M., Buchholz, F., Harb, H. & Link, T. & 3 others, Wimberger, P., Theis, M. & Kuhlmann, J. D., Mar 2025, In: Cancer Gene Therapy. 32, 3, p. 286-296 11 p., e50155.

Research output: Contribution to journal › Research article › Contributed › peer-review

A pooled CRISPR screen identifies the Tα2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes

Schönberg, P. Y. (First author), Muñoz-Ovalle, Á., Paszkowski-Rogacz, M., Crespo, E., Sürün, D., Feldmann, A. & Buchholz, F., 2025, In: Frontiers in immunology. 16, 1536003.

Research output: Contribution to journal › Research article › Contributed › peer-review

Epigenetic silencing of the TCR complex in CAR-T cells: Development and application for allogenic immunotherapy

Schönberg, P., 2025

Research output: Types of thesis › Doctoral thesis

The histone modifier KAT2A presents a selective target in a subset of well-differentiated microsatellite-stable colorectal cancers

Kufrin, V., Seiler, A., Brilloff, S., Rothfuß, H., Küchler, S., Schäfer, S. & Rahimian, E. & 8 others, Baumgarten, J., Ding, L., Buchholz, F., Ball, C. R., Bornhäuser, M., Glimm, H., Bill, M. & Wurm, A. A., 2025, (Accepted/In press) In: Cell death and differentiation. 8.

Research output: Contribution to journal › Research article › Contributed › peer-review

Activation of recombinases at specific DNA loci by zinc-finger domain insertions

Mukhametzyanova, L., Schmitt, L. T., Torres-Rivera, J., Rojo-Romanos, T., Lansing, F., Paszkowski-Rogacz, M. & Hollak, H. & 4 others, Brux, M., Augsburg, M., Schneider, P. M. & Buchholz, F., Dec 2024, In: Nature biotechnology. 42, 12, p. 1844-1854 11 p.

Research output: Contribution to journal › Research article › Contributed › peer-review

View all research output (145)

Krankenhauspharmazie

ISSNs: 0173-7597

Additional searchable ISSN (electronic): 0173-7597

Deutscher Apotheker Verlag, Germany

Scopus rating (2023): CiteScore 0.1 SJR 0.138 SNIP 0.122

Journal

Nature Reviews. Methods Primers

Additional searchable ISSN (electronic): 2662-8449

Springer Nature, United Kingdom

Scopus rating (2023): CiteScore 46.1 SJR 12.294 SNIP 13.074

Journal

Cancer Gene Therapy

ISSNs: 0929-1903

Additional searchable ISSN (electronic): 1476-5500

Springer Nature, United States of America

Scopus rating (2023): CiteScore 10.2 SJR 1.457 SNIP 0.903

Journal

GEN : genetic engineering & biotechnology news ; biotechnology from bench to business

ISSNs: 0270-6377

Additional searchable ISSN (electronic): 1937-8661

Mary Ann Liebert Publishers, Larchmont, United States of America

Journal

Cellular oncology : the official journal of the International Society for Cellular Oncology

ISSNs: 2211-3428

Additional searchable ISSN (electronic): 2211-3436

Springer Science and Business Media B.V., Germany

Scopus rating (2023): CiteScore 10.3 SJR 1.489 SNIP 1.031

Indexed in DOAJ

Journal

View all journals (71)

Zinc finger recombinases

Buchholz, F. (Speaker)

12 May 2025 → 16 May 2025

Activity: Talk or presentation at external institutions/events › Talk/Presentation › Invited

Site-specific recombinases, Swiss Army Knives in the genome engineering tool-box

Buchholz, F. (Speaker)

10 Apr 2025

Activity: Talk or presentation at external institutions/events › Talk/Presentation › Invited

DG-GT Annual Meeting 2025

Buchholz, F. (Member of programme committee)

10 Mar 2025 → 11 Mar 2025

Activity: Organising or participating in an event › Organising an event

FVIII intron 1 inversion editing

Buchholz, F. (Speaker)

7 Nov 2024

Activity: Talk or presentation at external institutions/events › Talk/Presentation › Invited

Engineering Designer-Recombinases for therapeutic genome editing

Buchholz, F. (Speaker)

23 Oct 2024

Activity: Talk or presentation at external institutions/events › Talk/Presentation › Invited

View all activities (178)

Dr. Walter Seipp-Preis of the Commerzbank Foundation

Mukhametzyanova, L. (Recipient), 27 Oct 2024

Prize: Other prize

Immunotherapeutic targeting of glioblastoma using Fn14-redirected RevCAR effector cells; Immuntherapeutische Behandlung von Glioblastomen mit Fn14-gesteuerten RevCAR-Effektorzellen

Saleh Hassan, H. (Recipient), 18 Apr 2024

Prize: Publication/Conference prize

Carl-Gustav-Carus-Förderpreis 2024

Jelicic, M. (Recipient), 2024

Prize: PhD Thesis Prize

DRESDEN EXCELENCE AWARD

Schmitt, L. T. (Recipient), 2024

Prize: PhD Thesis Prize

UNIPRENEURS chair

Buchholz, F. (Recipient), 6 Sept 2023

Prize: Innovation/transfer prize

View all prizes (21)

You ask We explain

Buchholz, F.

22 Mar 2023

1 Media contribution

Press/Media

Genomchirurgie zum Nachhören - Genom-Chirurgie in der Humanmedizin. Gibt es bald die lang ersehnten Fortschritte in der Gentherapie?

Buchholz, F.

21 Feb 2017

1 Media contribution

Press/Media

WELT - Forscher schneiden erstmals Aids-Virus aus Zellen heraus

Buchholz, F.

23 Feb 2016

1 Media contribution

Press/Media

ntv - Mit molekularem Skalpell: Menschliche Zellen von HI-Virus befreit

Buchholz, F.

23 Feb 2016

1 Media contribution

Press/Media

Schneiden, drehen, kleben

Buchholz, F.

30 Jun 2023

1 item of Media coverage

Press/Media

View all press/media (9)