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Prof. Dr. Mike O. Karl

Person

Research interests

The MOKALAB investigates mechanisms of neurodegeneration in the human retina, and its regenerative potential. We are particularly interested in age-related macular degeneration (AMD), one of the most common causes of vision loss worldwide. With the help of human retinal organoids and cell systems, we hope to contribute to new therapeutic strategies to prevent vision loss and to restore retinal cell, structure and function.

External positions

Research Group Leader, German Center for Neurodegenerative Diseases (DZNE)

1 Oct 2012 → …

Identification Numbers

ORCID Orcid 0000-0002-0926-6556, external link
Scopus author ID 10039901400
Researcher ID E-7246-2010

Related content

Live Imaging Microscopy of Human Retina Organoids: Photoreceptor Pathology

Wagner, F. & Karl, M. O., 2025, Retinal Degenerative Diseases XX: Mechanisms and Experimental Therapy. Springer, Cham, Vol. 1468. p. 383–387 5 p. (Advances in experimental medicine and biology : AEMB, Vol. 1468).

Research output: Contribution to book/Conference proceedings/Anthology/Report › Conference contribution › Contributed › peer-review

Epigenome profiling identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis

Ditzer, N., Şenoğlu, E., Schütze, T. M., Nikolaidi, A., Kolodziejczyk, A., Sameith, K. & Dietz, S. & 9 others, Derihaci, R. P., Birdir, C., Eugster, A., Karl, M. O., Dahl, A., Wimberger, P., Baenke, F., Peitzsch, C. & Albert, M., 2 Oct 2024.

Research output: Preprint/Documentation/Report › Preprint

Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts

Carido, M., Völkner, M., Steinheuer, L. M., Wagner, F., Kurth, T., Dumler, N. & Ulusoy, S. & 11 others, Wieneke, S., Norniella, A. V., Golfieri, C., Khattak, S., Schönfelder, B., Scamozzi, M., Zoschke, K., Canzler, S., Hackermüller, J., Ader, M. & Karl, M. O., 6 Oct 2023, In: Frontiers in cellular neuroscience. 17 (2023), 26 p., 1166641.

Research output: Contribution to journal › Research article › Contributed › peer-review

Modeling inducible neuropathologies of the retina with differential phenotypes in organoids

Völkner, M., Wagner, F., Kurth, T., Sykes, A. M., Del Toro Runzer, C., Ebner, L. J. A. & Kavak, C. & 5 others, Alexaki, V. I., Cimalla, P., Mehner, M., Koch, E. & Karl, M. O., 2023, In: Frontiers in cellular neuroscience. 17, 1106287.

Research output: Contribution to journal › Research article › Contributed › peer-review

HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids

Völkner, M., Wagner, F., Steinheuer, L. M., Carido, M., Kurth, T., Yazbeck, A. & Schor, J. & 11 others, Wieneke, S., Ebner, L. J. A., Runzer, C. D. T., Taborsky, D., Zoschke, K., Vogt, M., Canzler, S., Hermann, A., Khattak, S., Hackermüller, J. & Karl, M. O., 19 Oct 2022, In: Nature communications. 13, 1, 6183.

Research output: Contribution to journal › Research article › Contributed › peer-review

View all research output (63)