Working situation and burden of work limitations in sarcoma patients: results from the multi-center prospective PROSa study

Research output: Contribution to journalResearch articleContributedpeer-review



Purpose: We investigated predictors of limitations in work performance, odds of drop out of work, and odds of receiving disability pension in sarcoma patients. Methods: We measured clinical and sociodemographic data in adult sarcoma patients and recorded if the patients received a (1) disability pension at baseline or (2) had dropped out of work 1 year after initial assessment. (3) Work limitations were assessed using the Work-limitations questionnaire (WLQ©). We analyzed exploratively. Results: (1) Amongst 364 analyzed patients, odds to receive a disability pension were higher in patients with abdominal tumors, older patients, high grade patients and with increasing time since diagnosis. (2) Of 356 patients employed at baseline, 21% (n = 76) had dropped out of work after 1 year. The odds of dropping out of work were higher in bone sarcoma patients and in patients who received additive radiotherapy ± systemic therapy compared with patients who received surgery alone. Odds of dropping out of work were less amongst self-employed patients and dropped with increasing time since diagnosis. (3) Work limitations were higher in woman and increased with age. Patients with bone and fibrous sarcomas were more affected than liposarcoma patients. Patients with abdominal tumors reported highest restrictions. Sarcoma treatment in the last 6 months increased work limitations. Conclusion: Work limitations, drop out of work and dependence on a disability pension occurs frequently in patients with sarcoma adding to the burden of this condition. We were able to identify vulnerable groups in both the socioeconomic and disease categories.


Original languageEnglish
Pages (from-to)6009-6021
Number of pages13
JournalJournal of cancer research and clinical oncology
Issue number9
Publication statusPublished - Aug 2023

External IDs

PubMed 36624191
ORCID /0000-0001-9654-2207/work/142254138


Research priority areas of TU Dresden

Sustainable Development Goals

ASJC Scopus subject areas


  • Disability pension, Drop out of work, Limitations at work, Rare diseases, Return to work, Sarcoma, Work-limitations questionnaire, Working situation, Sarcoma/therapy, Prospective Studies, Humans, Pensions, Adult, Female, Disabled Persons

Library keywords