Typ-I-Interferonopathien: Durch Typ-1-Interferone bedingte entzündliche Systemerkrankungen
Research output: Contribution to journal › Editorial (Lead article) › Contributed › peer-review
Contributors
Abstract
Type I interferons mediate immune defense against viral infections. The induction of type I interferons has stimulating and modulating effects on the innate and adaptive immune systems thereby reducing tolerance against self-antigens. Genetic defects that result in an inadequate activation of the type I interferon system can cause a group of inflammatory disorders, which are collectively referred to as type I interferonopathies. While the clinical spectrum of type I interferonopathies is broad and heterogeneous, neurological and cutaneous symptoms are the most frequent manifestations. Some clinical and genetic features of type I interferonopathies are shared by multifactorial diseases, such as systemic lupus erythematosus and systemic vasculitis. Advances in understanding the disease mechanisms underlying type I interferonopathies have pinpointed novel targets for therapeutic interventions.
Translated title of the contribution | Type I interferonopathies Systemic inflammatory diseases triggered by type I interferons |
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Details
Original language | German |
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Pages (from-to) | 134-140 |
Number of pages | 7 |
Journal | Zeitschrift fur Rheumatologie |
Volume | 75 |
Issue number | 2 |
Publication status | Published - 1 Mar 2016 |
Peer-reviewed | Yes |
External IDs
researchoutputwizard | legacy.publication#72397 |
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Scopus | 84961144473 |
PubMed | 26744186 |
ORCID | /0000-0002-4330-1861/work/148606005 |
Keywords
ASJC Scopus subject areas
Keywords
- Autoimmunity, Autoinflammation, Immune system, Monogenic diseases, Systemic lupus erythematosus