Typ-I-Interferonopathien: Durch Typ-1-Interferone bedingte entzündliche Systemerkrankungen
Publikation: Beitrag in Fachzeitschrift › Leitartikel (Editorial) › Beigetragen › Begutachtung
Beitragende
Abstract
Type I interferons mediate immune defense against viral infections. The induction of type I interferons has stimulating and modulating effects on the innate and adaptive immune systems thereby reducing tolerance against self-antigens. Genetic defects that result in an inadequate activation of the type I interferon system can cause a group of inflammatory disorders, which are collectively referred to as type I interferonopathies. While the clinical spectrum of type I interferonopathies is broad and heterogeneous, neurological and cutaneous symptoms are the most frequent manifestations. Some clinical and genetic features of type I interferonopathies are shared by multifactorial diseases, such as systemic lupus erythematosus and systemic vasculitis. Advances in understanding the disease mechanisms underlying type I interferonopathies have pinpointed novel targets for therapeutic interventions.
Details
Originalsprache | Deutsch |
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Seiten (von - bis) | 134-140 |
Seitenumfang | 7 |
Fachzeitschrift | Zeitschrift fur Rheumatologie |
Jahrgang | 75 |
Ausgabenummer | 2 |
Publikationsstatus | Veröffentlicht - 1 März 2016 |
Peer-Review-Status | Ja |
Externe IDs
researchoutputwizard | legacy.publication#72397 |
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Scopus | 84961144473 |
PubMed | 26744186 |
ORCID | /0000-0002-4330-1861/work/148606005 |
Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Autoimmunity, Autoinflammation, Immune system, Monogenic diseases, Systemic lupus erythematosus