They Are Not Too Excited: The Possible Role of Adult-Born Neurons in Epilepsy

Research output: Contribution to journalShort survey/reviewContributedpeer-review

Contributors

  • Gerd Kempermann - , Max Delbrück Center for Molecular Medicine (MDC) (Author)

Abstract

In a new study in this issue of Neuron, Jakubs and colleagues report that adult-generated hippocampal granule cells develop particular functional properties when their birth is induced by epileptic seizures. The new neurons showed reduced excitatory synaptic input and decreased excitability. Their functional integration was thus adjusted to the prevailing functional state in the network. By this means, adult neurogenesis might contribute to network homeostasis in the epileptic temporal lobe.

Details

Original languageEnglish
Pages (from-to)935-937
Number of pages3
JournalNeuron
Volume52
Issue number6
Publication statusPublished - 21 Dec 2006
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 17178397
ORCID /0000-0002-5304-4061/work/152544220

Keywords

ASJC Scopus subject areas