They Are Not Too Excited: The Possible Role of Adult-Born Neurons in Epilepsy

Publikation: Beitrag in FachzeitschriftKurze Umfrage/ÜbersichtsartikelBeigetragenBegutachtung

Beitragende

  • Gerd Kempermann - , Max-Delbrück-Centrum für Molekulare Medizin (MDC) (Autor:in)

Abstract

In a new study in this issue of Neuron, Jakubs and colleagues report that adult-generated hippocampal granule cells develop particular functional properties when their birth is induced by epileptic seizures. The new neurons showed reduced excitatory synaptic input and decreased excitability. Their functional integration was thus adjusted to the prevailing functional state in the network. By this means, adult neurogenesis might contribute to network homeostasis in the epileptic temporal lobe.

Details

OriginalspracheEnglisch
Seiten (von - bis)935-937
Seitenumfang3
FachzeitschriftNeuron
Jahrgang52
Ausgabenummer6
PublikationsstatusVeröffentlicht - 21 Dez. 2006
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 17178397
ORCID /0000-0002-5304-4061/work/152544220

Schlagworte

ASJC Scopus Sachgebiete