The mammalian gene function resource: The International Knockout Mouse Consortium

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Allan Bradley - , Wellcome Sanger Institute (Author)
  • Konstantinos Anastassiadis - , Biotechnology Center (Author)
  • Abdelkader Ayadi - , University of Strasbourg (Author)
  • James F. Battey - , National Institutes of Health (NIH) (Author)
  • Cindy Bell - , Genome Canada (Author)
  • Marie Christine Birling - , University of Strasbourg (Author)
  • Joanna Bottomley - , Wellcome Sanger Institute (Author)
  • Steve D. Brown - , Medical Research Council (MRC) (Author)
  • Antje Bürger - , Technical University of Munich (Author)
  • Carol J. Bult - , Jackson Laboratory (Author)
  • Wendy Bushell - , Wellcome Sanger Institute (Author)
  • Francis S. Collins - , National Institutes of Health (NIH) (Author)
  • Christian Desaintes - , European Commission (Author)
  • Brendan Doe - , National Research Council of Italy (CNR) (Author)
  • Economides Aris - , Regeneron Pharmaceuticals, Inc. (Author)
  • Janan T. Eppig - , Jackson Laboratory (Author)
  • Richard H. Finnell - , Texas A&M University, University of Texas at Austin (Author)
  • Colin Fletcher - , National Institutes of Health (NIH) (Author)
  • Martin Fray - , Medical Research Council (MRC) (Author)
  • David Frendewey - , Regeneron Pharmaceuticals, Inc. (Author)
  • Roland H. Friedel - , Technical University of Munich, Icahn School of Medicine at Mount Sinai (Author)
  • Frank G. Grosveld - , Erasmus University Rotterdam (Author)
  • Jens Hansen - , Technical University of Munich (Author)
  • Yann Hérault - , University of Strasbourg (Author)
  • Geoffrey Hicks - , University of Manitoba (Author)
  • Andreas Hörlein - , Technical University of Munich (Author)
  • Richard Houghton - , Wellcome Sanger Institute (Author)
  • Martin Hrabé De Angelis - , University of Manitoba (Author)
  • Danny Huylebroeck - , KU Leuven (Author)
  • Vivek Iyer - , Wellcome Sanger Institute (Author)
  • Pieter J. De Jong - , UCSF Benioff Children's Hospital Oakland (Author)
  • James A. Kadin - , Jackson Laboratory (Author)
  • Cornelia Kaloff - , Technical University of Munich (Author)
  • Karen Kennedy - , Wellcome Sanger Institute (Author)
  • Manousos Koutsourakis - , Wellcome Sanger Institute (Author)
  • K. C. Kent Lloyd - , University of California at Davis (Author)
  • Susan Marschall - , Helmholtz Zentrum München - German Research Center for Environmental Health (Author)
  • Jeremy Mason - , Jackson Laboratory (Author)
  • Colin McKerlie - , University of Toronto (Author)
  • Michael P. McLeod - , Texas A&M University (Author)
  • Harald Von Melchner - , Goethe University Frankfurt a.M. (Author)
  • Mark Moore - , National Institutes of Health (NIH) (Author)
  • Alejandro O. Mujica - , Wellcome Sanger Institute, Regeneron Pharmaceuticals, Inc. (Author)
  • Andras Nagy - , University of Toronto (Author)
  • Mikhail Nefedov - , UCSF Benioff Children's Hospital Oakland (Author)
  • Lauryl M. Nutter - , University of Toronto (Author)
  • Guillaume Pavlovic - , University of Strasbourg (Author)
  • Jane L. Peterson - , National Institutes of Health (NIH) (Author)
  • Jonathan Pollock - , National Institutes of Health (NIH) (Author)
  • Ramiro Ramirez-Solis - , Wellcome Sanger Institute (Author)
  • Derrick E. Rancourt - , University of Calgary (Author)
  • Marcello Raspa - , National Research Council of Italy (CNR) (Author)
  • Jacques E. Remacle - , European Commission (Author)
  • Martin Ringwald - , Jackson Laboratory (Author)
  • Barry Rosen - , Wellcome Sanger Institute (Author)
  • Nadia Rosenthal - , European Molecular Biology Laboratory (EMBL) Monterotondo (Author)
  • Janet Rossant - , University of Toronto (Author)
  • Patricia Ruiz Noppinger - , Charité – Universitätsmedizin Berlin (Author)
  • Ed Ryder - , Wellcome Sanger Institute (Author)
  • Joel Zupicich Schick - , Technical University of Munich (Author)
  • Frank Schnütgen - , Goethe University Frankfurt a.M. (Author)
  • Paul Schofield - , University of Cambridge (Author)
  • Claudia Seisenberger - , Technical University of Munich (Author)
  • Mohammed Selloum - , University of Strasbourg (Author)
  • Elizabeth M. Simpson - , University of British Columbia (Author)
  • William C. Skarnes - , Wellcome Sanger Institute (Author)
  • Damian Smedley - , Wellcome Sanger Institute, EMBL European Bioinformatics Institute (EBI) (Author)
  • William L. Stanford - , University of Ottawa (Author)
  • A. Francis Stewart - , Chair of Applied Genomics (Author)
  • Kevin Stone - , Jackson Laboratory (Author)
  • Kate Swan - , Genome Canada (Author)
  • Hamsa Tadepally - , Jackson Laboratory (Author)
  • Lydia Teboul - , Medical Research Council (MRC) (Author)
  • Glauco P. Tocchini-Valentini - , National Research Council of Italy (CNR) (Author)
  • David Valenzuela - , Regeneron Pharmaceuticals, Inc. (Author)
  • Anthony P. West - , Wellcome Sanger Institute (Author)
  • Ken Ichi Yamamura - , Kumamoto University (Author)
  • Yuko Yoshinaga - , UCSF Benioff Children's Hospital Oakland (Author)
  • Wolfgang Wurst - , Technical University of Munich, Max Planck Institute of Psychiatry, German Center for Neurodegenerative Diseases (DZNE) (Author)

Abstract

In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed highthroughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Details

Original languageEnglish
Pages (from-to)580-586
Number of pages7
JournalMammalian Genome
Volume23
Issue number9-10
Publication statusPublished - Oct 2012
Peer-reviewedYes

External IDs

PubMed 22968824
ORCID /0000-0002-4754-1707/work/170586825

Keywords

ASJC Scopus subject areas