The mammalian gene function resource: The International Knockout Mouse Consortium

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Allan Bradley - , Wellcome Sanger Institute (Autor:in)
  • Konstantinos Anastassiadis - , Biotechnologisches Zentrum (BIOTEC) (Autor:in)
  • Abdelkader Ayadi - , Université de Strasbourg (Autor:in)
  • James F. Battey - , National Institutes of Health (NIH) (Autor:in)
  • Cindy Bell - , Genome Canada (Autor:in)
  • Marie Christine Birling - , Université de Strasbourg (Autor:in)
  • Joanna Bottomley - , Wellcome Sanger Institute (Autor:in)
  • Steve D. Brown - , Medical Research Council (MRC) (Autor:in)
  • Antje Bürger - , Technische Universität München (Autor:in)
  • Carol J. Bult - , Jackson Laboratory (Autor:in)
  • Wendy Bushell - , Wellcome Sanger Institute (Autor:in)
  • Francis S. Collins - , National Institutes of Health (NIH) (Autor:in)
  • Christian Desaintes - , European Commission (Autor:in)
  • Brendan Doe - , National Research Council of Italy (CNR) (Autor:in)
  • Economides Aris - , Regeneron Pharmaceuticals, Inc. (Autor:in)
  • Janan T. Eppig - , Jackson Laboratory (Autor:in)
  • Richard H. Finnell - , Texas A&M University, University of Texas at Austin (Autor:in)
  • Colin Fletcher - , National Institutes of Health (NIH) (Autor:in)
  • Martin Fray - , Medical Research Council (MRC) (Autor:in)
  • David Frendewey - , Regeneron Pharmaceuticals, Inc. (Autor:in)
  • Roland H. Friedel - , Technische Universität München, Icahn School of Medicine at Mount Sinai (Autor:in)
  • Frank G. Grosveld - , Erasmus University Rotterdam (Autor:in)
  • Jens Hansen - , Technische Universität München (Autor:in)
  • Yann Hérault - , Université de Strasbourg (Autor:in)
  • Geoffrey Hicks - , University of Manitoba (Autor:in)
  • Andreas Hörlein - , Technische Universität München (Autor:in)
  • Richard Houghton - , Wellcome Sanger Institute (Autor:in)
  • Martin Hrabé De Angelis - , University of Manitoba (Autor:in)
  • Danny Huylebroeck - , KU Leuven (Autor:in)
  • Vivek Iyer - , Wellcome Sanger Institute (Autor:in)
  • Pieter J. De Jong - , UCSF Benioff Children's Hospital Oakland (Autor:in)
  • James A. Kadin - , Jackson Laboratory (Autor:in)
  • Cornelia Kaloff - , Technische Universität München (Autor:in)
  • Karen Kennedy - , Wellcome Sanger Institute (Autor:in)
  • Manousos Koutsourakis - , Wellcome Sanger Institute (Autor:in)
  • K. C. Kent Lloyd - , University of California at Davis (Autor:in)
  • Susan Marschall - , Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (Autor:in)
  • Jeremy Mason - , Jackson Laboratory (Autor:in)
  • Colin McKerlie - , University of Toronto (Autor:in)
  • Michael P. McLeod - , Texas A&M University (Autor:in)
  • Harald Von Melchner - , Johann Wolfgang Goethe-Universität Frankfurt am Main (Autor:in)
  • Mark Moore - , National Institutes of Health (NIH) (Autor:in)
  • Alejandro O. Mujica - , Wellcome Sanger Institute, Regeneron Pharmaceuticals, Inc. (Autor:in)
  • Andras Nagy - , University of Toronto (Autor:in)
  • Mikhail Nefedov - , UCSF Benioff Children's Hospital Oakland (Autor:in)
  • Lauryl M. Nutter - , University of Toronto (Autor:in)
  • Guillaume Pavlovic - , Université de Strasbourg (Autor:in)
  • Jane L. Peterson - , National Institutes of Health (NIH) (Autor:in)
  • Jonathan Pollock - , National Institutes of Health (NIH) (Autor:in)
  • Ramiro Ramirez-Solis - , Wellcome Sanger Institute (Autor:in)
  • Derrick E. Rancourt - , University of Calgary (Autor:in)
  • Marcello Raspa - , National Research Council of Italy (CNR) (Autor:in)
  • Jacques E. Remacle - , European Commission (Autor:in)
  • Martin Ringwald - , Jackson Laboratory (Autor:in)
  • Barry Rosen - , Wellcome Sanger Institute (Autor:in)
  • Nadia Rosenthal - , European Molecular Biology Laboratory (EMBL) Monterotondo (Autor:in)
  • Janet Rossant - , University of Toronto (Autor:in)
  • Patricia Ruiz Noppinger - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Ed Ryder - , Wellcome Sanger Institute (Autor:in)
  • Joel Zupicich Schick - , Technische Universität München (Autor:in)
  • Frank Schnütgen - , Johann Wolfgang Goethe-Universität Frankfurt am Main (Autor:in)
  • Paul Schofield - , University of Cambridge (Autor:in)
  • Claudia Seisenberger - , Technische Universität München (Autor:in)
  • Mohammed Selloum - , Université de Strasbourg (Autor:in)
  • Elizabeth M. Simpson - , University of British Columbia (Autor:in)
  • William C. Skarnes - , Wellcome Sanger Institute (Autor:in)
  • Damian Smedley - , Wellcome Sanger Institute, EMBL European Bioinformatics Institute (EBI) (Autor:in)
  • William L. Stanford - , University of Ottawa (Autor:in)
  • A. Francis Stewart - , Professur für Biotechnologische Genomik (Autor:in)
  • Kevin Stone - , Jackson Laboratory (Autor:in)
  • Kate Swan - , Genome Canada (Autor:in)
  • Hamsa Tadepally - , Jackson Laboratory (Autor:in)
  • Lydia Teboul - , Medical Research Council (MRC) (Autor:in)
  • Glauco P. Tocchini-Valentini - , National Research Council of Italy (CNR) (Autor:in)
  • David Valenzuela - , Regeneron Pharmaceuticals, Inc. (Autor:in)
  • Anthony P. West - , Wellcome Sanger Institute (Autor:in)
  • Ken Ichi Yamamura - , Kumamoto University (Autor:in)
  • Yuko Yoshinaga - , UCSF Benioff Children's Hospital Oakland (Autor:in)
  • Wolfgang Wurst - , Technische Universität München, Max Planck Institute of Psychiatry, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) (Autor:in)

Abstract

In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed highthroughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Details

OriginalspracheEnglisch
Seiten (von - bis)580-586
Seitenumfang7
FachzeitschriftMammalian Genome
Jahrgang23
Ausgabenummer9-10
PublikationsstatusVeröffentlicht - Okt. 2012
Peer-Review-StatusJa

Externe IDs

PubMed 22968824
ORCID /0000-0002-4754-1707/work/170586825

Schlagworte

ASJC Scopus Sachgebiete