The making of insulin in health and disease
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes. [Figure not available: see fulltext.]
Details
Original language | English |
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Pages (from-to) | 1981-1989 |
Number of pages | 9 |
Journal | Diabetologia |
Volume | 63 |
Issue number | 10 |
Publication status | Published - 1 Oct 2020 |
Peer-reviewed | Yes |
External IDs
PubMed | 32894308 |
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Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Beta cell, Insulin biosynthesis, Insulin maturation, Post-transcriptional regulation, Proinsulin conversion, Review, Type 1 diabetes, Type 2 diabetes