The making of insulin in health and disease
Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel (Review) › Beigetragen › Begutachtung
Beitragende
Abstract
The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes. [Figure not available: see fulltext.]
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 1981-1989 |
Seitenumfang | 9 |
Fachzeitschrift | Diabetologia |
Jahrgang | 63 |
Ausgabenummer | 10 |
Publikationsstatus | Veröffentlicht - 1 Okt. 2020 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 32894308 |
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Schlagworte
Ziele für nachhaltige Entwicklung
ASJC Scopus Sachgebiete
Schlagwörter
- Beta cell, Insulin biosynthesis, Insulin maturation, Post-transcriptional regulation, Proinsulin conversion, Review, Type 1 diabetes, Type 2 diabetes