Thalassiosira pseudonana(Cyclotella nana) (Hustedt) Hasle et Heimdal (Bacillariophyceae): A genetically tractable model organism for studying diatom biology, including biological silica formation

Research output: Contribution to journalResearch articleInvitedpeer-review


In 2004, Thalassiosira pseudonana was the first eukaryotic marine alga to have its genome sequenced. Since then, this species has quickly emerged as a valuable model species for investigating the molecular underpinnings of essentially all aspects of diatom life, particularly bio-morphogenesis of the cell wall. An important prerequisite for the model status of T. pseudonana is the ongoing development of increasingly precise tools to study the function of gene networks and their encoded proteins in vivo. Here, we briefly review the current toolbox for genetic manipulation, highlight specific examples of its application in studying diatom metabolism, and provide a peek into the role of diatoms in the emerging field of silica biotechnology.


Original languageEnglish
Pages (from-to)809-817
Number of pages9
JournalJournal of Phycology
Issue number5
Early online dateJul 2023
Publication statusPublished - Oct 2023

External IDs

PubMed 37424141
Scopus 85164589452
Mendeley d0487a1c-eb4e-3698-bb4a-5eabd0e93ca0
ORCID /0000-0002-4533-8860/work/142241046


Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Subject groups, research areas, subject areas according to Destatis

Sustainable Development Goals

ASJC Scopus subject areas


  • Algae, Diatom, Genetic engineering, Model, Molecular, algae, diatom, genetic engineering, model, molecular, Biology, Diatoms/genetics, Silicon Dioxide/metabolism, Genome