Stiffness-dependent in vitro uptake and lysosomal acidification of colloidal particles
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
The physico-chemical properties of colloidal particles determine their uptake into cells. For a series of microparticles only one parameter, the mechanical stiffness, was varied, whereas other parameters such as size, shape, and charge were kept constant. The uptake was monitored in situ by analyzing individual particle trajectories including the progress of endocytosis, derived from local pH measurements around each particle. Evidence is presented that soft particles with low stiffness are transported faster to lysosomes than stiffer ones.
Details
Original language | English |
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Pages (from-to) | 1365-1368 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 54 |
Issue number | 4 |
Publication status | Published - 19 Jan 2015 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 25483403 |
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Keywords
ASJC Scopus subject areas
Keywords
- Biosensors, Mechanical properties, Nanoparticles, Polymeric capsules