Stiffness-dependent in vitro uptake and lysosomal acidification of colloidal particles
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
The physico-chemical properties of colloidal particles determine their uptake into cells. For a series of microparticles only one parameter, the mechanical stiffness, was varied, whereas other parameters such as size, shape, and charge were kept constant. The uptake was monitored in situ by analyzing individual particle trajectories including the progress of endocytosis, derived from local pH measurements around each particle. Evidence is presented that soft particles with low stiffness are transported faster to lysosomes than stiffer ones.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 1365-1368 |
Seitenumfang | 4 |
Fachzeitschrift | Angewandte Chemie - International Edition |
Jahrgang | 54 |
Ausgabenummer | 4 |
Publikationsstatus | Veröffentlicht - 19 Jan. 2015 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMed | 25483403 |
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Schlagworte
ASJC Scopus Sachgebiete
Schlagwörter
- Biosensors, Mechanical properties, Nanoparticles, Polymeric capsules