The role of PTFE in tailoring the tribological performance of PEEK is not clear from the literature, and conflicting evidence is reported about its ability to improve friction, wear, or both. Moreover, little has been reported on the optimum composition of such blends for the best possible combination of mechanical and tribological properties. Hence, in this work various blends of PEEK with PTFE have been injection moulded and characterised for their mechanical properties. Their friction and wear behaviour was evaluated using a pin-on-disc machine. It was observed that the inclusion of PTFE powder not only removed scuffing problems associated with the friction behaviour of PEEK, but also improved both friction and wear characteristics. A blend with 7.5 wt.% PTFE showed the best wear behaviour, while a blend with 30 wt.% PTFE exhibited the best friction performance. A concentration of 7.5 wt.% PTFE was thought to be the optimum amount for the best possible combination of mechanical and tribological properties.