Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D

Johannes Soltwedel; Theresa Suckert; Elke Beyreuther; Moritz Schneider; Marc Boucsein; Elisabeth Bodenstein; Sindi Nexhipi; Liane Stolz-Kieslich; Mechthild Krause; Cläre von Neubeck; Robert Haase; Armin Lühr; Antje Dietrich

doi:10.1016/j.radonc.2023.109591

Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

Johannes Soltwedel - , Core Facility Bio-image Analysis, Department of Radiation Oncology, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf (Author)
Theresa Suckert - , Department of Radiation Oncology, TUD Dresden University of Technology, German Cancer Research Center (DKFZ), Institute for Research in Biomedicine (Author)
Elke Beyreuther - , TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, OncoRay - National Centre for Radiation Research in Oncology (Author)
Moritz Schneider - , Department of Radiation Oncology, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf (Author)
Marc Boucsein - , Heidelberg University (Author)
Elisabeth Bodenstein - , OncoRay ZIC - National Center for Radiation Research in Oncology (Partners: UKD, HZDR), TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf (Author)
Sindi Nexhipi - , OncoRay ZIC - National Center for Radiation Research in Oncology (Partners: UKD, HZDR), Department of Radiation Oncology, TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf (Author)
Liane Stolz-Kieslich - , TUD Dresden University of Technology, German Cancer Research Center (DKFZ), OncoRay - National Centre for Radiation Research in Oncology (Author)
Mechthild Krause - , Department of Radiation Oncology, National Center for Tumor Diseases (Partners: UKD, MFD, HZDR, DKFZ), OncoRay ZIC - National Center for Radiation Research in Oncology (Partners: UKD, HZDR), TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, German Cancer Research Center (DKFZ), University Hospital Carl Gustav Carus Dresden (Author)
Cläre von Neubeck - , TUD Dresden University of Technology, German Cancer Research Center (DKFZ), University of Duisburg-Essen (Author)
Robert Haase - , Core Facility Bio-image Analysis, TUD Dresden University of Technology (Author)
Armin Lühr - , TUD Dresden University of Technology, Helmholtz-Zentrum Dresden-Rossendorf, Dortmund University of Technology (Author)
Antje Dietrich - , TUD Dresden University of Technology, German Cancer Research Center (DKFZ), OncoRay - National Centre for Radiation Research in Oncology (Author)

Abstract

Comprehending cellular changes of radiation-induced brain injury is crucial to prevent and treat the pathology. We provide a unique open dataset of proton-irradiated mouse brains consisting of medical imaging, radiation dose simulations, and large-scale microscopy images, all registered into a common coordinate system. This allows dose-dependent analyses on single-cell level.

Details

Original language	English
Article number	109591
Journal	Radiotherapy and oncology
Volume	182
Publication status	Published - May 2023
Peer-reviewed	Yes

External IDs

PubMed	36858201
ORCID	/0000-0003-1899-603X/work/147142596

Keywords

ASJC Scopus subject areas

Hematology
Oncology
Radiology, Nuclear Medicine and Imaging

Keywords

Multimodal Imaging, Normal tissue toxicity, Open Data, Preclinical mouse brain irradiation, Proton therapy, Radiation-induced brain injury, Brain Injuries/diagnostic imaging, Radiography, Brain/diagnostic imaging, Animals, Microscopy, Radiation Injuries/prevention & control, Mice

Research Portal of the TU Dresden

Contributors

Abstract

Details

External IDs

Keywords

ASJC Scopus subject areas

Keywords