Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Melissa A. Munn-Chernoff - , University of North Carolina at Chapel Hill (Author)
  • Emma C. Johnson - , Washington University St. Louis (Author)
  • Yi Ling Chou - , Washington University St. Louis (Author)
  • Jonathan R.I. Coleman - , King's College London (KCL), South London and Maudsley NHS Foundation Trust (Author)
  • Laura M. Thornton - , University of North Carolina at Chapel Hill (Author)
  • Raymond K. Walters - , Massachusetts General Hospital, Broad Institute of Harvard University and MIT (Author)
  • Zeynep Yilmaz - , University of North Carolina at Chapel Hill (Author)
  • Jessica H. Baker - , University of North Carolina at Chapel Hill (Author)
  • Christopher Hübel - , King's College London (KCL), South London and Maudsley NHS Foundation Trust, Karolinska Institutet (Author)
  • Scott Gordon - , Queensland Institute of Medical Research (Author)
  • Sarah E. Medland - , Queensland Institute of Medical Research (Author)
  • Hunna J. Watson - , University of North Carolina at Chapel Hill, Curtin University, University of Western Australia (Author)
  • Héléna A. Gaspar - , King's College London (KCL), South London and Maudsley NHS Foundation Trust (Author)
  • Julien Bryois - , Karolinska Institutet (Author)
  • Anke Hinney - , University of Duisburg-Essen (Author)
  • Virpi M. Leppä - , Karolinska Institutet (Author)
  • Manuel Mattheisen - , Aarhus University, Karolinska Institutet, Stockholm County Council, University of Würzburg (Author)
  • Stephan Ripke - , Massachusetts General Hospital, Broad Institute of Harvard University and MIT, Charité – Universitätsmedizin Berlin (Author)
  • Shuyang Yao - , Karolinska Institutet (Author)
  • Paola Giusti-Rodríguez - , University of North Carolina at Chapel Hill (Author)
  • Ken B. Hanscombe - , King's College London (KCL) (Author)
  • Roger A.H. Adan - , Utrecht University, Altrecht Mental Health Institute, University of Gothenburg (Author)
  • Lars Alfredsson - , Karolinska Institutet (Author)
  • Tetsuya Ando - , National Center of Neurology and Psychiatry Kodaira (Author)
  • Ole A. Andreassen - , University of Oslo (Author)
  • Wade H. Berrettini - , University of Pennsylvania (Author)
  • Ilka Boehm - , Division of Psychological and Social Medicine and Developmental Neurosciences (Author)
  • Claudette Boni - , INSERM - Institut national de la santé et de la recherche médicale (Author)
  • Vesna Boraska Perica - , Wellcome Sanger Institute, University of Split (Author)
  • Katharina Buehren - , RWTH Aachen University (Author)
  • Roland Burghardt - , Klinikum Frankfurt (Oder) (Author)
  • Matteo Cassina - , University of Padua (Author)
  • Sven Cichon - , University of Basel, Jülich Research Centre (Author)
  • Maurizio Clementi - , University of Padua (Author)
  • Roger D. Cone - , University of Michigan, Ann Arbor (Author)
  • Philippe Courtet - , University of Montpellier (Author)
  • Scott Crow - , University of Minnesota System (Author)
  • James J. Crowley - , University of North Carolina at Chapel Hill, Karolinska Institutet (Author)
  • Unna N. Danner - , Altrecht Mental Health Institute (Author)
  • Oliver S.P. Davis - , University of Bristol (Author)
  • Martina de Zwaan - , Hannover Medical School (MHH) (Author)
  • George Dedoussis - , Harokopio University (Author)
  • Daniela Degortes - , University of Padua (Author)
  • Janiece E. DeSocio - , Seattle University (Author)
  • Danielle M. Dick - , Virginia Commonwealth University (Author)
  • Dimitris Dikeos - , National and Kapodistrian University of Athens (Author)
  • Christian Dina - , Université de Nantes (Author)
  • Monika Dmitrzak-Weglarz - , University of Medical Sciences Poznan (Author)
  • Elisa Docampo - , Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network (Author)
  • Laramie E. Duncan - , Stanford University (Author)
  • Karin Egberts - , University of Würzburg (Author)
  • Stefan Ehrlich - , Division of Psychological and Social Medicine and Developmental Neurosciences (Author)
  • Geòrgia Escaramís - , Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network (Author)
  • Tõnu Esko - , Estonian Biocentre, Broad Institute of Harvard University and MIT (Author)
  • Xavier Estivill - , Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network, CRG - Centre for Genomic Regulation (Author)
  • Anne Farmer - , King's College London (KCL) (Author)
  • Angela Favaro - , University of Padua (Author)
  • Fernando Fernández-Aranda - , University Hospital of Bellvitge, University of Barcelona (Author)
  • Manfred M. Fichter - , Ludwig Maximilian University of Munich (Author)
  • Krista Fischer - , Estonian Biocentre (Author)
  • Manuel Föcker - , University of Münster (Author)
  • Lenka Foretova - , Masaryk Memorial Cancer Institute (Author)
  • Andreas J. Forstner - , University of Basel, University of Marburg, University of Bonn (Author)
  • Monica Forzan - , University of Padua (Author)
  • Christopher S. Franklin - , Wellcome Sanger Institute (Author)
  • Steven Gallinger - , University of Toronto (Author)
  • Ina Giegling - , Martin Luther University Halle-Wittenberg (Author)
  • Johanna Giuranna - , University of Duisburg-Essen (Author)
  • Fragiskos Gonidakis - , National and Kapodistrian University of Athens (Author)
  • Philip Gorwood - , GHU Paris Psychiatrie & Neuro sciences, Université Paris Cité (Author)
  • Monica Gratacos Mayora - , Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network (Author)
  • Sébastien Guillaume - , University of Montpellier (Author)
  • Yiran Guo - , University of Pennsylvania (Author)
  • Hakon Hakonarson - , University of Pennsylvania (Author)
  • Konstantinos Hatzikotoulas - , Wellcome Sanger Institute, Helmholtz Zentrum München - German Research Center for Environmental Health (Author)
  • Joanna Hauser - , University of Medical Sciences Poznan (Author)
  • Johannes Hebebrand - , University of Duisburg-Essen (Author)
  • Sietske G. Helder - , King's College London (KCL), Zorg op Orde (Author)
  • Stefan Herms - , University of Basel (Author)
  • Beate Herpertz-Dahlmann - , RWTH Aachen University (Author)
  • Wolfgang Herzog - , Heidelberg University  (Author)
  • Laura M. Huckins - , Wellcome Sanger Institute, Icahn School of Medicine at Mount Sinai (Author)
  • James I. Hudson - , Harvard University (Author)
  • Hartmut Imgart - , Eating Disorders Unit (Author)
  • Hidetoshi Inoko - , Tokai University (Author)
  • Vladimir Janout - , Palacký University Olomouc (Author)
  • Susana Jiménez-Murcia - , University Hospital of Bellvitge, University of Barcelona (Author)
  • Antonio Julià - , Vall d'Hebron Research Institute (VHIR) (Author)
  • Gursharan Kalsi - , King's College London (KCL) (Author)
  • Deborah Kaminská - , Charles University Prague (Author)
  • Leila Karhunen - , University of Eastern Finland (Author)
  • Andreas Karwautz - , Medical University of Vienna (Author)
  • Martien J.H. Kas - , Utrecht University, University of Groningen (Author)
  • James L. Kennedy - , University of Toronto (Author)
  • Anna Keski-Rahkonen - , University of Helsinki (Author)
  • Kirsty Kiezebrink - , University of Aberdeen (Author)
  • Youl Ri Kim - , Inje University (Author)
  • Kelly L. Klump - , Michigan State University (Author)
  • Gun Peggy S. Knudsen - , Norwegian Institute of Public Health (Author)
  • Maria C. La Via - , University of North Carolina at Chapel Hill (Author)
  • Stephanie Le Hellard - , University of Bergen, Haukeland universitets­sjukehus (Author)
  • Robert D. Levitan - , University of Toronto (Author)
  • Dong Li - , University of Pennsylvania (Author)
  • Lisa Lilenfeld - , The Chicago School of Professional Psychology (Author)
  • Bochao Danae Lin - , Utrecht University (Author)
  • Jolanta Lissowska - , Maria Sklodowska-Curie Institute of Oncology (Author)
  • Jurjen Luykx - , Utrecht University (Author)
  • Pierre J. Magistretti - , King Abdullah University of Science and Technology, University of Lausanne (Author)
  • Mario Maj - , University of Campania Luigi Vanvitelli (Author)
  • Katrin Mannik - , Estonian Biocentre, University of Lausanne (Author)
  • Sara Marsal - , Vall d'Hebron Research Institute (VHIR) (Author)
  • Christian R. Marshall - , University of Toronto (Author)
  • Morten Mattingsdal - , University of Oslo (Author)
  • Sara McDevitt - , University College Cork, Mid-Western Regional Hospital Limerick (Author)
  • Peter McGuffin - , King's College London (KCL) (Author)
  • Andres Metspalu - , Estonian Biocentre, University of Tartu (Author)
  • Ingrid Meulenbelt - , Leiden University (Author)
  • Nadia Micali - , University of Geneva, Geneva University Hospitals (Author)
  • Karen Mitchell - , Department of Veterans Affairs, Boston University (Author)
  • Alessio Maria Monteleone - , University of Campania Luigi Vanvitelli (Author)
  • Palmiero Monteleone - , University of Salerno (Author)
  • Benedetta Nacmias - , University of Florence (Author)
  • Marie Navratilova - , Masaryk Memorial Cancer Institute (Author)
  • Ioanna Ntalla - , Harokopio University (Author)
  • Julie K. O'Toole - , Kartini Clinic (Author)
  • Roel A. Ophoff - , University of California at Los Angeles, Erasmus University Rotterdam (Author)
  • Leonid Padyukov - , Karolinska Institutet (Author)
  • Aarno Palotie - , Broad Institute of Harvard University and MIT, University of Helsinki, Massachusetts General Hospital (Author)
  • Jacques Pantel - , INSERM - Institut national de la santé et de la recherche médicale (Author)
  • Hana Papezova - , Charles University Prague (Author)
  • Dalila Pinto - , Icahn School of Medicine at Mount Sinai (Author)
  • Raquel Rabionet - , Hospital Sant Joan de Déu Barcelona, University of Barcelona (Author)
  • Anu Raevuori - , University of Helsinki (Author)
  • Nicolas Ramoz - , GHU Paris Psychiatrie & Neuro sciences (Author)
  • Ted Reichborn-Kjennerud - , Norwegian Institute of Public Health, University of Oslo (Author)
  • Valdo Ricca - , University of Florence (Author)
  • Samuli Ripatti - , University of Helsinki (Author)
  • Franziska Ritschel - , Division of Psychological and Social Medicine and Developmental Neurosciences, Department of Child and Adolescent Psychiatry and Psychotherapy (Author)
  • Marion Roberts - , King's College London (KCL) (Author)
  • Alessandro Rotondo - , University of Pisa (Author)
  • Dan Rujescu - , Martin Luther University Halle-Wittenberg (Author)
  • Filip Rybakowski - , University of Medical Sciences Poznan (Author)
  • Paolo Santonastaso - , University of Padua (Author)
  • André Scherag - , Friedrich Schiller University Jena (Author)
  • Stephen W. Scherer - , University of Toronto (Author)
  • Ulrike Schmidt - , King's College London (KCL) (Author)
  • Nicholas J. Schork - , J. Craig Venter Institute (Author)
  • Alexandra Schosser - , Medical University of Vienna (Author)
  • Jochen Seitz - , RWTH Aachen University (Author)
  • Lenka Slachtova - , Charles University Prague (Author)
  • P. Eline Slagboom - , Leiden University (Author)
  • Margarita C.T. Slof-Op't Landt - , Center for Eating Disorders Ursula, Leiden University (Author)
  • Agnieszka Slopien - , University of Medical Sciences Poznan (Author)
  • Sandro Sorbi - , University of Florence, IRCCS S. Maria Nascente-Fondazione Don Carlo Gnocchi Onlus (Author)
  • Beata Świątkowska - , Nofer Institute of Occupational Medicine (Author)
  • Jin P. Szatkiewicz - , University of North Carolina at Chapel Hill (Author)
  • Ioanna Tachmazidou - , Wellcome Sanger Institute (Author)
  • Elena Tenconi - , University of Padua (Author)
  • Alfonso Tortorella - , University of Campania Luigi Vanvitelli, University of Perugia (Author)
  • Federica Tozzi - , STREMBLE Ventures Ltd. (Author)
  • Janet Treasure - , King's College London (KCL) (Author)
  • Artemis Tsitsika - , National and Kapodistrian University of Athens (Author)
  • Marta Tyszkiewicz-Nwafor - , University of Medical Sciences Poznan (Author)
  • Konstantinos Tziouvas - , National and Kapodistrian University of Athens (Author)
  • Annemarie A. van Elburg - , Altrecht Mental Health Institute, Utrecht University (Author)
  • Eric F. van Furth - , Center for Eating Disorders Ursula, Leiden University (Author)
  • Gudrun Wagner - , Medical University of Vienna (Author)
  • Esther Walton - , TUD Dresden University of Technology (Author)
  • Elisabeth Widen - , University of Helsinki (Author)
  • Eleftheria Zeggini - , Wellcome Sanger Institute, Helmholtz Zentrum München - German Research Center for Environmental Health (Author)
  • Stephanie Zerwas - , University of North Carolina at Chapel Hill (Author)
  • Stephan Zipfel - , University Hospital Tübingen (Author)
  • Andrew W. Bergen - , BioRealm LLC, Oregon Research Institute (Author)
  • Joseph M. Boden - , University of Otago (Author)
  • Harry Brandt - , The Center for Eating Disorders (Author)
  • Steven Crawford - , The Center for Eating Disorders (Author)
  • Katherine A. Halmi - , Cornell University (Author)
  • L. John Horwood - , University of Otago (Author)
  • Craig Johnson - , Eating Recovery Center Colorado (Author)
  • Allan S. Kaplan - , University of Toronto (Author)
  • Walter H. Kaye - , University of California at San Diego (Author)
  • James Mitchell - , University of North Dakota (Author)
  • Catherine M. Olsen - , Queensland Institute of Medical Research (Author)
  • John F. Pearson - , University of Otago (Author)
  • Nancy L. Pedersen - , Karolinska Institutet (Author)
  • Michael Strober - , University of California at Los Angeles (Author)
  • Thomas Werge - , University of Copenhagen (Author)
  • David C. Whiteman - , Queensland Institute of Medical Research (Author)
  • D. Blake Woodside - , University of Toronto (Author)
  • Jakob Grove - , Aarhus University, The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) (Author)
  • Anjali K. Henders - , University of Queensland (Author)
  • Janne T. Larsen - , The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University (Author)
  • Richard Parker - , Queensland Institute of Medical Research (Author)
  • Liselotte V. Petersen - , The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University (Author)
  • Jennifer Jordan - , University of Otago, Canterbury District Health Board (Author)
  • Martin A. Kennedy - , University of Otago (Author)
  • Andreas Birgegård - , Karolinska Institutet, Stockholm County Council (Author)
  • Paul Lichtenstein - , Karolinska Institutet (Author)
  • Claes Norring - , Karolinska Institutet, Stockholm County Council (Author)
  • Mikael Landén - , Karolinska Institutet, University of Gothenburg (Author)
  • Preben Bo Mortensen - , The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University (Author)
  • Renato Polimanti - , Yale University, Department of Veterans Affairs (Author)
  • Jeanette N. McClintick - , Indiana University-Purdue University Indianapolis (Author)
  • Amy E. Adkins - , Virginia Commonwealth University (Author)
  • Fazil Aliev - , Virginia Commonwealth University, Karabuk University (Author)
  • Silviu Alin Bacanu - , Virginia Commonwealth University (Author)
  • Anthony Batzler - , Mayo Clinic Rochester, MN (Author)
  • Sarah Bertelsen - , Icahn School of Medicine at Mount Sinai (Author)
  • Joanna M. Biernacka - , Mayo Clinic Rochester, MN (Author)
  • Tim B. Bigdeli - , SUNY Downstate Health Sciences University (Author)
  • Li Shiun Chen - , Washington University St. Louis (Author)
  • Toni Kim Clarke - , University of Edinburgh (Author)
  • Franziska Degenhardt - , University of Bonn (Author)
  • Anna R. Docherty - , University of Utah (Author)
  • Alexis C. Edwards - , Virginia Commonwealth University (Author)
  • Jerome C. Foo - , Heidelberg University  (Author)
  • Louis Fox - , Washington University St. Louis (Author)
  • Josef Frank - , Heidelberg University  (Author)
  • Laura M. Hack - , Stanford University (Author)
  • Annette M. Hartmann - , Martin Luther University Halle-Wittenberg (Author)
  • Sarah M. Hartz - , Washington University St. Louis (Author)
  • Stefanie Heilmann-Heimbach - , University of Bonn (Author)
  • Colin Hodgkinson - , National Institutes of Health (NIH) (Author)
  • Per Hoffmann - , University of Basel, University of Bonn (Author)
  • Jouke Jan Hottenga - , University of Amsterdam (Author)
  • Bettina Konte - , Martin Luther University Halle-Wittenberg (Author)
  • Jari Lahti - , University of Turku (Author)
  • Marius Lahti-Pulkkinen - , University of Helsinki (Author)
  • Dongbing Lai - , Indiana University-Purdue University Indianapolis (Author)
  • Lannie Ligthart - , University of Amsterdam (Author)
  • Anu Loukola - , University of Helsinki (Author)
  • Brion S. Maher - , Johns Hopkins University (Author)
  • Hamdi Mbarek - , University of Amsterdam (Author)
  • Andrew M. McIntosh - , University of Edinburgh (Author)
  • Matthew B. McQueen - , University of Colorado Boulder (Author)
  • Jacquelyn L. Meyers - , SUNY Downstate Health Sciences University (Author)
  • Yuri Milaneschi - , Vrije Universiteit Amsterdam (VU) (Author)
  • Teemu Palviainen - , University of Helsinki (Author)
  • Roseann E. Peterson - , Virginia Commonwealth University (Author)
  • Euijung Ryu - , Mayo Clinic Rochester, MN (Author)
  • Nancy L. Saccone - , Washington University St. Louis (Author)
  • Jessica E. Salvatore - , Virginia Commonwealth University (Author)
  • Sandra Sanchez-Roige - , University of California at San Diego (Author)
  • Melanie Schwandt - , National Institutes of Health (NIH) (Author)
  • Richard Sherva - , Boston University (Author)
  • Fabian Streit - , Heidelberg University  (Author)
  • Jana Strohmaier - , Heidelberg University  (Author)
  • Nathaniel Thomas - , Virginia Commonwealth University (Author)
  • Jen Chyong Wang - , Icahn School of Medicine at Mount Sinai (Author)
  • Bradley T. Webb - , Virginia Commonwealth University (Author)
  • Robbee Wedow - , Massachusetts General Hospital, Broad Institute of Harvard University and MIT, Harvard University (Author)
  • Leah Wetherill - , Indiana University-Purdue University Indianapolis (Author)
  • Amanda G. Wills - , University of Colorado Denver (Author)
  • Hang Zhou - , Yale University, Department of Veterans Affairs (Author)
  • Jason D. Boardman - , University of Colorado Boulder (Author)
  • Danfeng Chen - , Broad Institute of Harvard University and MIT (Author)
  • Doo Sup Choi - , Mayo Clinic College of Medicine and Science (Author)
  • William E. Copeland - , University of Vermont (Author)
  • Robert C. Culverhouse - , Washington University St. Louis (Author)
  • Norbert Dahmen - , Johannes Gutenberg University Mainz (Author)
  • Louisa Degenhardt - , University of New South Wales (Author)
  • Benjamin W. Domingue - , Stanford University (Author)
  • Mark A. Frye - , Mayo Clinic Rochester, MN (Author)
  • Wolfgang Gäebel - , Heinrich Heine University Düsseldorf (Author)
  • Caroline Hayward - , University of Edinburgh (Author)
  • Marcus Ising - , Max Planck Institute of Psychiatry (Author)
  • Margaret Keyes - , University of Minnesota System (Author)
  • Falk Kiefer - , Heidelberg University  (Author)
  • Gabriele Koller - , Ludwig Maximilian University of Munich (Author)
  • John Kramer - , University of Iowa (Author)
  • Samuel Kuperman - , University of Iowa (Author)
  • Susanne Lucae - , Max Planck Institute of Psychiatry (Author)
  • Michael T. Lynskey - , King's College London (KCL) (Author)
  • Wolfgang Maier - , University of Bonn (Author)
  • Karl Mann - , Heidelberg University  (Author)
  • Satu Männistö - , National Institute for Health and Welfare (Author)
  • Bertram Müller-Myhsok - , Max Planck Institute of Psychiatry (Author)
  • Alison D. Murray - , University of Aberdeen (Author)
  • John I. Nurnberger - , Indiana University-Purdue University Indianapolis (Author)
  • Ulrich Preuss - , Martin Luther University Halle-Wittenberg, Vitos Hospital Herborn (Author)
  • Katri Räikkönen - , University of Helsinki (Author)
  • Maureen D. Reynolds - , University of Pittsburgh (Author)
  • Monika Ridinger - , University of Regensburg (Author)
  • Norbert Scherbaum - , University of Duisburg-Essen (Author)
  • Marc A. Schuckit - , University of California at San Diego (Author)
  • Michael Soyka - , Ludwig Maximilian University of Munich (Author)
  • Jens Treutlein - , Heidelberg University  (Author)
  • Stephanie H. Witt - , Heidelberg University  (Author)
  • Norbert Wodarz - , University of Regensburg (Author)
  • Peter Zill - , Ludwig Maximilian University of Munich (Author)
  • Daniel E. Adkins - , University of Utah (Author)
  • Dorret I. Boomsma - , University of Amsterdam (Author)
  • Laura J. Bierut - , Washington University St. Louis (Author)
  • Sandra A. Brown - , University of California at San Diego (Author)
  • Kathleen K. Bucholz - , Washington University St. Louis (Author)
  • E. Jane Costello - , Duke University (Author)
  • Harriet de Wit - , The University of Chicago (Author)
  • Nancy Diazgranados - , National Institutes of Health (NIH) (Author)
  • Johan G. Eriksson - , University of Helsinki, National Institute for Health and Welfare (Author)
  • Lindsay A. Farrer - , Boston University (Author)
  • Tatiana M. Foroud - , Indiana University-Purdue University Indianapolis (Author)
  • Nathan A. Gillespie - , Virginia Commonwealth University (Author)
  • Alison M. Goate - , Icahn School of Medicine at Mount Sinai (Author)
  • David Goldman - , National Institutes of Health (NIH), National Institute on Alcohol Abuse and Alcoholism (Author)
  • Richard A. Grucza - , Washington University St. Louis (Author)
  • Dana B. Hancock - , RTI International (Author)
  • Kathleen Mullan Harris - , University of North Carolina at Chapel Hill (Author)
  • Victor Hesselbrock - , University of Connecticut (Author)
  • John K. Hewitt - , University of Colorado Boulder (Author)
  • Christian J. Hopfer - , University of Colorado Denver (Author)
  • William G. Iacono - , University of Minnesota System (Author)
  • Eric O. Johnson - , RTI International (Author)
  • Victor M. Karpyak - , Mayo Clinic Rochester, MN (Author)
  • Kenneth S. Kendler - , Virginia Commonwealth University (Author)
  • Henry R. Kranzler - , University of Pennsylvania, VA Medical Center (Author)
  • Kenneth Krauter - , University of Colorado Boulder (Author)
  • Penelope A. Lind - , Queensland Institute of Medical Research (Author)
  • Matt McGue - , University of Minnesota System (Author)
  • James MacKillop - , McMaster University (Author)
  • Pamela A.F. Madden - , Washington University St. Louis (Author)
  • Hermine H. Maes - , Virginia Commonwealth University (Author)
  • Patrik K.E. Magnusson - , Karolinska Institutet (Author)
  • Elliot C. Nelson - , Washington University St. Louis (Author)
  • Markus M. Nöthen - , University of Bonn (Author)
  • Abraham A. Palmer - , University of California at San Diego (Author)
  • Brenda W.J.H. Penninx - , Vrije Universiteit Amsterdam (VU) (Author)
  • Bernice Porjesz - , SUNY Downstate Health Sciences University (Author)
  • John P. Rice - , Washington University St. Louis (Author)
  • Marcella Rietschel - , Heidelberg University  (Author)
  • Brien P. Riley - , Virginia Commonwealth University (Author)
  • Richard J. Rose - , Indiana University Bloomington (Author)
  • Pei Hong Shen - , National Institutes of Health (NIH) (Author)
  • Judy Silberg - , Virginia Commonwealth University (Author)
  • Michael C. Stallings - , University of Colorado Boulder (Author)
  • Ralph E. Tarter - , University of Pittsburgh (Author)
  • Michael M. Vanyukov - , University of Pittsburgh (Author)
  • Scott Vrieze - , University of Minnesota System (Author)
  • Tamara L. Wall - , University of California at San Diego (Author)
  • John B. Whitfield - , Queensland Institute of Medical Research (Author)
  • Hongyu Zhao - , Yale University (Author)
  • Benjamin M. Neale - , Massachusetts General Hospital, Broad Institute of Harvard University and MIT (Author)
  • Tracey D. Wade - , Flinders University (Author)
  • Andrew C. Heath - , Washington University St. Louis (Author)
  • Grant W. Montgomery - , Queensland Institute of Medical Research, University of Queensland (Author)
  • Nicholas G. Martin - , Queensland Institute of Medical Research (Author)
  • Patrick F. Sullivan - , University of North Carolina at Chapel Hill, Karolinska Institutet (Author)
  • Jaakko Kaprio - , University of Helsinki (Author)
  • Gerome Breen - , King's College London (KCL), South London and Maudsley NHS Foundation Trust (Author)
  • Joel Gelernter - , Yale University, Department of Veterans Affairs (Author)
  • Howard J. Edenberg - , Indiana University-Purdue University Indianapolis (Author)
  • Cynthia M. Bulik - , University of North Carolina at Chapel Hill, Karolinska Institutet (Author)
  • Arpana Agrawal - , Washington University St. Louis (Author)

Abstract

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

Details

Original languageEnglish
Article numbere12880
JournalAddiction biology
Volume26
Issue number1
Publication statusPublished - Jan 2021
Peer-reviewedYes

External IDs

PubMed 32064741
ORCID /0000-0003-2132-4445/work/160950862

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • eating disorders, genetic correlation, substance use