Semi-structural adhesive joints with hyperelastic polyurethane adhesives and large adhesive layer thicknesses enable the realization of innovative hybrid lightweight designs with fiber reinforced plastic (FRP) composites. The design of these adhesively bonded joints with complex mechanical behavior requires a valid and efficient method for computational service life prediction. In this paper, a submodel-based service strength analysis method for adhesively bonded hybrid structures is presented and validated on sub component fatigue tests. The submodel strategy is generalized by periodic boundary conditions to evaluate failure relevant stresses and thus fatigue life in advance and independently from the global structure analysis.