Seizure forecasting with ultra long-term EEG signals
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Objective: The apparent randomness of seizure occurrence affects greatly the quality of life of persons with epilepsy. Since seizures are often phase-locked to multidien cycles of interictal epileptiform activity, a recent forecasting scheme, exploiting RNS data, is capable of forecasting seizures days in advance. Methods: We tested the use of a bandpass filter to capture the universal mid-term dynamics enabling both patient-specific and cross-patient forecasting. In a retrospective study, we explored the feasibility of the scheme on three long-term recordings obtained by the NeuroPace RNS System, the NeuroVista intracranial, and the UNEEG subcutaneous devices, respectively. Results: Better-than-chance forecasting was observed in 15 (83 %) of 18 patients, and in 16 (89 %) patients for daily and hourly forecast, respectively. Meaningful forecast up to 30 days could be achieved in 4 (22 %) patients for hourly forecast frequency. The cross-patient performance decreased only marginally and was patient-wise strongly correlated with the patient-specific one. Comparable performance was obtained for NeuroVista and UNEEG data sets. Significance: The feasibility of cross-patient forecasting supports the universal importance of mid-term dynamics for seizure forecasting, demonstrates promising inter-subject-applicability of the scheme on ultra long-term EEG recordings, and highlights its huge potential for clinical use.
Details
| Original language | English |
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| Pages (from-to) | 211-220 |
| Number of pages | 10 |
| Journal | Clinical Neurophysiology |
| Volume | 167 |
| Publication status | Published - Nov 2024 |
| Peer-reviewed | Yes |
External IDs
| ORCID | /0000-0001-7436-0103/work/172566318 |
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| ORCID | /0000-0001-9875-3534/work/172568323 |
Keywords
ASJC Scopus subject areas
Keywords
- Cross-patient forecasting, Cycles in epilepsy, Seizure forecasting