Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration

Li, W., Luo, X., Poetsch, M. S., Oertel, R., Nichani, K., Schneider, M., Strano, A., & 8 othersHasse, M., Steiner, R. P., Cyganek, L., Hettwer, K., Uhlig, S., Simon, K., Guan, K. & Schubert, M., Feb 2022, In: Pharmaceuticals. 15, 2, 24 p., 220.

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IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency

Luo, X., Li, W., Künzel, K., Henze, S., Cyganek, L., Strano, A., Poetsch, M. S., & 2 othersSchubert, M. & Guan, K., 12 Aug 2020, In: Frontiers in cell and developmental biology. 8, 772.

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Electrophysiological abnormalities in VLCAD deficient hiPSC-cardiomyocytes can be improved by lowering accumulation of fatty acid oxidation intermediates

Knottnerus, S. J. G., Mengarelli, I., Wüst, R. C. I., Baartscheer, A., Bleeker, J. C., Coronel, R., Ferdinandusse, S., & 12 othersGuan, K., Ijlst, L., Li, W., Luo, X., Portero, V. M., Ulbricht, Y., Visser, G., Wanders, R. J. A., Wijburg, F. A., Verkerk, A. O., Houtkooper, R. H. & Bezzina, C. R., 1 Apr 2020, In: International journal of molecular sciences. 21, 7, 2589.

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Establishment of an automated patch-clamp platform for electrophysiological and pharmacological evaluation of hiPSC-CMs

Li, W., Luo, X., Ulbricht, Y., Wagner, M., Piorkowski, C., El-Armouche, A. & Guan, K., Dec 2019, In: Stem cell research. 41, 101662.

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Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT₁-fragment domains in cardiomyocytes

Weninger, G., Pochechueva, T., El Chami, D., Luo, X., Kohl, T., Brandenburg, S., Urlaub, H., & 3 othersGuan, K., Lenz, C. & Lehnart, S. E., Dec 2022, In: Scientific reports. 12, 1, 17 p., 10387.

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A calcineurin-mediated scaling mechanism that controls a K⁺-leak channel to regulate morphogen and growth factor transcription

Yi, C., Spitters, T. W. G. M., Al-Far, E. A. D. A., Wang, S., Xiong, T., Cai, S., Yan, X., & 4 othersGuan, K., Wagner, M., El-Armouche, A. & Antos, C. L., Apr 2021, In: eLife. 10, e60691.

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Electrophysiological Abnormalities in VLCAD Deficient hiPSC-Cardiomyocytes Do not Improve with Carnitine Supplementation

Verkerk, A. O., Knottnerus, S. J. G., Portero, V., Bleeker, J. C., Ferdinandusse, S., Guan, K., IJlst, L., & 6 othersVisser, G., Wanders, R. J. A., Wijburg, F. A., Bezzina, C. R., Mengarelli, I. & Houtkooper, R. H., 12 Jan 2021, In: Frontiers in pharmacology. 11, 616834.

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Induced pluripotent stem cells of patients with Tetralogy of Fallot reveal transcriptional alterations in cardiomyocyte differentiation

Grunert, M., Appelt, S., Schönhals, S., Mika, K., Cui, H., Cooper, A., Cyganek, L., & 2 othersGuan, K. & Sperling, S. R., 1 Dec 2020, In: Scientific reports. 10, 1, 10921.

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Targeting miR128-3p alleviates myocardial insulin resistance and prevents ischemia- induced heart failure

Ruiz-Velasco, A., Zi, M., Hille, S. S., Azam, T., Kaur, N., Jiang, J., Nguyen, B., & 11 othersSekeres, K., Binder, P., Collins, L., Pu, F., Xiao, H., Guan, K., Frey, N., Cartwright, E. J., Müller, O. J., Wang, X. & Liu, W., Mar 2020, In: eLife. 9, e54298.

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Control of p21^Cip by BRCA1-associated protein is critical for cardiomyocyte cell cycle progression and survival

Volland, C., Schott, P., Didié, M., Männer, J., Unsöld, B., Toischer, K., Schmidt, C., & 7 othersUrlaub, H., Nickels, K., Knöll, R., Schmidt, A., Guan, K., Hasenfuß, G. & Seidler, T., 1 Mar 2020, In: Cardiovascular research. 116, 3, p. 592-604 13 p.

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