Hybrid metal-composite structures offer high potential in lightweight engineering. These hybrid structures combine different materials to create components that are far ahead of the classic designs in terms of strength, stiffness and weight. Next to the advantages, the manufacturing of such components is highly complex. Additionally, increasing requirements of the components effect increasing engineering effort. The multitude of adjustable and interacting parameters leads to a complex and multi-disciplinary product development process. The correlations and interactions of the process and disturbance parameters on the properties are partly unknown for hybrid lightweight structures. For a reliable manufacturing process with low defect and reject rates it is essential to monitor the process and material properties during production. In this paper, a concept is presented how non-destructive testing (NDT) can be integrated into the development process model of hybrid metal-composites. A methodical approach to modelling the product development process is used, describing the methods and models used in the process, as well as the generated data. Moreover, several NDT methods were evaluated for quality assurance of hybrid metal-composites.