RNA interference: gene silencing in the fast lane
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Sequencing of whole genomes has provided new perspectives into the blueprints of diverse organisms. Knowing the sequences, however, does not always tell us much about the function of the genes that regulate development and homeostasis. RNA interference (RNAi) is becoming the method of choice for gene function analysis in cells and whole organisms. Here we review the approaches available to perform RNAi experiments in mammalian cells and in mice. We discuss usage of RNAi in cancer research and as a possible therapeutic tool for cancer treatment.
Details
Original language | English |
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Pages (from-to) | 259-65 |
Number of pages | 7 |
Journal | Seminars in cancer biology |
Volume | 13 |
Issue number | 4 |
Publication status | Published - Aug 2003 |
Peer-reviewed | Yes |
External IDs
Scopus | 0642307773 |
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Keywords
Sustainable Development Goals
Keywords
- Animals, Genetic Therapy/methods, Humans, Neoplasms/genetics, RNA Interference/physiology, RNA, Small Interfering/biosynthesis