Reversible switching of microtubule motility using thermoresponsive polymer surfaces
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
We report a novel approach for the dynamic control of gliding microtubule motility by external stimuli. Our approach is based on the fabrication of a composite surface where functional kinesin motor-molecules are adsorbed onto a silicon substrate between surface-grafted polymer chains of thermoresponsive poly(N-isopropylacrylamide). By external temperature control between 27 and 35°C, we demonstrate the reversible landing, gliding, and releasing of motor-driven microtubules in response to conformational changes of the polymer chains. Our method represents a versatile means to control the activity of biomolecular motors, and other surface-coupled enzyme systems, in bionanotechnological applications.
Details
Original language | English |
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Pages (from-to) | 1982-1987 |
Number of pages | 6 |
Journal | Nano letters |
Volume | 6 |
Issue number | 9 |
Publication status | Published - Sept 2006 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 16968012 |
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ORCID | /0000-0002-0750-8515/work/142235584 |