Reversible switching of microtubule motility using thermoresponsive polymer surfaces
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
We report a novel approach for the dynamic control of gliding microtubule motility by external stimuli. Our approach is based on the fabrication of a composite surface where functional kinesin motor-molecules are adsorbed onto a silicon substrate between surface-grafted polymer chains of thermoresponsive poly(N-isopropylacrylamide). By external temperature control between 27 and 35°C, we demonstrate the reversible landing, gliding, and releasing of motor-driven microtubules in response to conformational changes of the polymer chains. Our method represents a versatile means to control the activity of biomolecular motors, and other surface-coupled enzyme systems, in bionanotechnological applications.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 1982-1987 |
Seitenumfang | 6 |
Fachzeitschrift | Nano letters |
Jahrgang | 6 |
Ausgabenummer | 9 |
Publikationsstatus | Veröffentlicht - Sept. 2006 |
Peer-Review-Status | Ja |
Extern publiziert | Ja |
Externe IDs
PubMed | 16968012 |
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ORCID | /0000-0002-0750-8515/work/142235584 |