Pulmonale Hypertonie assoziiert mit Lungenerkrankungen
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Lung diseases and hypoventilation syndromes are often associated with pulmonary hypertension (PH). In most cases, PH is not severe. This is defined hemodynamically by a mean pulmonary arterial pressure (PAPm) > 20 mmHg, a pulmonary arterial wedge pressure (PAWP) ≤ 15 mmHg and a pulmonary vascular resistance of ≤ 5 Wood units (WU). Both the non-severe (PVR ≤ 5 WU) and much more the severe PH (PVR > 5 WU) have an unfavorable prognosis.If PH is suspected, it is recommended to primarily check whether risk factors for pulmonary arterial hypertension (PAH, group 1 PH) or chronic thromboembolic pulmonary hypertension (CTEPH, group 4 PH) are present. If risk factors are present or there is a suspicion of severe PH in lung patients, it is recommended that the patient should be presented to a PH outpatient clinic promptly.For patients with severe PH associated with lung diseases, personalized, individual therapy is recommended - if possible within the framework of therapy studies. Currently, a therapy attempt with PH specific drugs should only be considered in COPD patients if the associated PH is severe and a "pulmonary vascular" phenotype (severe precapillary PH, but typically only mild to moderate airway obstruction, no or mild hypercapnia and DLCO < 45 % of predicted value) is present. In patients with severe PH associated with interstitial lung disease phosphodiesterase-5-inhibitors may be considered in individual cases. Inhaled treprostinil may be considered also in non-severe PH in this patient population.
Translated title of the contribution | Pulmonary hypertension associated with lung disease |
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Details
Original language | German |
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Pages (from-to) | 916-925 |
Number of pages | 10 |
Journal | Pneumologie |
Volume | 77 |
Issue number | 11 |
Publication status | Published - Nov 2023 |
Peer-reviewed | Yes |
External IDs
Scopus | 85177053458 |
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Keywords
Keywords
- Humans, Hypertension, Pulmonary/diagnosis, Lung, Vascular Resistance, Prognosis, Lung Diseases, Interstitial/diagnosis