Psychotic Like Experiences in Healthy Adolescents are Underpinned by Lower Fronto-Temporal Cortical Gyrification: a Study from the IMAGEN Consortium

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Raka Maitra - , King's College London (KCL) (Author)
  • Charlotte M. Horne - , King's College London (KCL) (Author)
  • Owen O'Daly - , King's College London (KCL) (Author)
  • Evangelos Papanastasiou - , King's College London (KCL), Boehringer Ingelheim GmbH (Author)
  • Christian Gaser - , Friedrich Schiller University Jena (Author)
  • Tobias Banaschewski - , Heidelberg University  (Author)
  • Gareth J. Barker - , King's College London (KCL) (Author)
  • Arun L.W. Bokde - , Trinity College Dublin (Author)
  • Sylvane Desrivières - , King's College London (KCL) (Author)
  • Herta Flor - , Heidelberg University , University of Mannheim (Author)
  • Antoine Grigis - , Université Paris-Saclay (Author)
  • Hugh Garavan - , University of Vermont (Author)
  • Penny Gowland - , University of Nottingham (Author)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Author)
  • Rüdiger Brühl - , Physikalisch-Technische Bundesanstalt (Author)
  • Jean Luc Martinot - , École normale supérieure Paris-Saclay (Author)
  • Marie Laure Paillère Martinot - , École normale supérieure Paris-Saclay, Assistance publique – Hôpitaux de Paris (Author)
  • Eric Artiges - , École normale supérieure Paris-Saclay, EPS Barthélémy Durand (Author)
  • Frauke Nees - , Heidelberg University , Humboldt University of Berlin (Author)
  • Dimitri Papadopoulos Orfanos - , Université Paris-Saclay (Author)
  • Herve Lemaitre - , Université Paris-Saclay, Université de Bordeaux (Author)
  • Tomáš Paus - , University of Montreal, University of Toronto (Author)
  • Luise Poustka - , University of Göttingen (Author)
  • Sarah Hohmann - , Heidelberg University  (Author)
  • Sabina Millenet - , Heidelberg University  (Author)
  • Juliane H. Fröhner - , Department of Psychiatry and Psychotherapy, Neuroimaging Center (Author)
  • Lauren Robinson - , King's College London (KCL) (Author)
  • Michael N. Smolka - , Department of Psychiatry and Psychotherapy, Neuroimaging Center (Author)
  • Henrik Walter - , Charité – Universitätsmedizin Berlin (Author)
  • Jeanne M. Winterer - , Charité – Universitätsmedizin Berlin, Free University of Berlin (Author)
  • Robert Whelan - , Trinity College Dublin (Author)
  • Erin Burke Quinlan - , King's College London (KCL) (Author)
  • Alex Ing - , King's College London (KCL) (Author)
  • Gunter Schumann - , King's College London (KCL), Humboldt University of Berlin, Leibniz Institute for Neurobiology, Fudan University (Author)
  • Sukhi Shergill - , King's College London (KCL), Kent and Medway Medical School (Author)

Abstract

Background and Hypothesis: Psychotic Like Experiences (PLEs) are widely prevalent in children and adolescents and increase the risk of developing psychosis. Cortical gyrification characterizes brain development from in utero till about the first 2 years of life and can be measured in later years as static gyrification changes demonstrating neurodevelopment and dynamic gyrification changes reflecting brain maturation during adolescence. We hypothesized that PLEs would be associated with static cortical gyrification changes reflecting a neurodevelopmental abnormality. Study Design: We studied 1252 adolescents recruited in the IMAGEN consortium. We used a longitudinal study design, with Magnetic Resonance Imaging measurements at age 14 years and age 19 years; measurement of PLEs using the Community Assessment of Psychic Experiences (CAPE) questionnaire at age 19 years; and clinical diagnoses at age 23 years. Study Results: Our results show static gyrification changes in adolescents with elevated PLEs on 3 items of the CAPE - voice hearing, unusual experiences of receiving messages, and persecutory ideas - with lower cortical gyrification in fronto-temporal regions in the left hemisphere. This group also demonstrated dynamic gyrification changes with higher cortical gyrification in right parietal cortex in late adolescence; a finding that we replicated in an independent sample of patients with first-episode psychosis. Adolescents with high PLEs were also 5.6 times more likely to transition to psychosis in adulthood by age 23 years. Conclusions: This is the largest study in adolescents that demonstrates fronto-temporal abnormality of cortical gyrification as a potential biomarker for vulnerability to PLEs and transition to psychosis.

Details

Original languageEnglish
Pages (from-to)309-318
Number of pages10
JournalSchizophrenia bulletin
Volume49
Issue number2
Publication statusPublished - 1 Mar 2023
Peer-reviewedYes

External IDs

ORCID /0000-0001-5398-5569/work/151982350
ORCID /0000-0002-8493-6396/work/151982798

Keywords

ASJC Scopus subject areas

Keywords

  • adolescence, cortical gyrification, IMAGEN, MRI, psychosis, psychotic like experiences