Protein interactions in 3D: from interface evolution to drug discovery
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Over the past 10years, much research has been dedicated to the understanding of protein interactions. Large-scale experiments to elucidate the global structure of protein interaction networks have been complemented by detailed studies of protein interaction interfaces. Understanding the evolution of interfaces allows one to identify convergently evolved interfaces which are evolutionary unrelated but share a few key residues and hence have common binding partners. Understanding interaction interfaces and their evolution is an important basis for pharmaceutical applications in drug discovery. Here, we review the algorithms and databases on 3D protein interactions and discuss in detail applications in interface evolution, drug discovery, and interface prediction.
Details
Original language | English |
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Pages (from-to) | 347-58 |
Number of pages | 12 |
Journal | Journal of Structural Biology: X |
Volume | 179 |
Issue number | 3 |
Publication status | Published - Sept 2012 |
Peer-reviewed | Yes |
External IDs
Scopus | 84865168586 |
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ORCID | /0000-0003-2848-6949/work/141543380 |
Keywords
Keywords
- Algorithms, Computer Simulation, Databases, Protein, Drug Discovery, Evolution, Molecular, Humans, Models, Molecular, Protein Binding, Protein Interaction Domains and Motifs, Protein Multimerization, Protein Structure, Quaternary, Protein Structure, Secondary, Proteins/chemistry