Protein enrichment by foam fractionation: Experiment and modeling

Research output: Contribution to journalResearch articleContributedpeer-review



This work investigates the enrichment of bovine serum albumin (BSA) protein through foam fractionation. Here, we performed experiments using BSA and measured the recovery and grade of the extract. Additionally, an unsteady-state simulation of the protein foam fractionation process was carried out by numerically solving the liquid drainage equation in the foam. Thereby, the extracted liquid volume and protein concentration were calculated. Required quantities such as foam stability, interface coverage or bubble size distribution were measured in corresponding experiments and were fed into the model. The experiments showed that the foam coalescence accelerates the liquid drainage leading to dryer extract and higher protein enrichment. The modeling also reproduced the liquid recovery and extract concentration of the foam fractionation tests within a reasonable error range. The modeling solely relies on experimental inputs and does not require any tuning parameters. It can be further used for optimization or up-scaling of protein foam fractionation.


Original languageEnglish
Article number117715
JournalChemical Engineering Science
Issue number256
Publication statusPublished - 20 Jul 2022

External IDs

Scopus 85130639249
unpaywall 10.1016/j.ces.2022.117715
WOS 000831019900007
Mendeley f7363fad-da46-34c1-bfcf-327810001267
ORCID /0000-0002-2912-546X/work/142238751
ORCID /0000-0002-2493-7629/work/142244928
ORCID /0000-0002-3102-2769/work/152545029


Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Subject groups, research areas, subject areas according to Destatis


  • Dynamic adsorption, Flotation, Flow-on-bubble, Foam fractionation, Modeling, Protein, Surface equation of state

Library keywords