Prediction of incidence and stability of alcohol use disorders by latent internalizing psychopathology risk profiles in adolescence and young adulthood
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Background Comorbid internalizing mental disorders in alcohol use disorders (AUD) can be understood as putative independent risk factors for AUD or as expressions of underlying shared psychopathology vulnerabilities. However, it remains unclear whether: 1) specific latent internalizing psychopathology risk-profiles predict AUD-incidence and 2) specific latent internalizing comorbidity-profiles in AUD predict AUD-stability. Aims To investigate baseline latent internalizing psychopathology risk profiles as predictors of subsequent AUD-incidence and -stability in adolescents and young adults. Methods Data from the prospective-longitudinal EDSP study (baseline age 14–24 years) were used. The study-design included up to three follow-up assessments in up to ten years. DSM-IV mental disorders were assessed with the DIA-X/M-CIDI. To investigate risk-profiles and their associations with AUD-outcomes, latent class analysis with auxiliary outcome variables was applied. Results AUD-incidence: a 4-class model (N = 1683) was identified (classes: normative-male [45.9%], normative-female [44.2%], internalizing [5.3%], nicotine dependence [4.5%]). Compared to the normative-female class, all other classes were associated with a higher risk of subsequent incident alcohol dependence (p < 0.05). AUD-stability: a 3-class model (N = 1940) was identified with only one class (11.6%) with high probabilities for baseline AUD. This class was further characterized by elevated substance use disorder (SUD) probabilities and predicted any subsequent AUD (OR 8.5, 95% CI 5.4–13.3). Conclusions An internalizing vulnerability may constitute a pathway to AUD incidence in adolescence and young adulthood. In contrast, no indication for a role of internalizing comorbidity profiles in AUD-stability was found, which may indicate a limited importance of such profiles – in contrast to SUD-related profiles – in AUD stability.
Details
Original language | English |
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Pages (from-to) | 32-41 |
Number of pages | 10 |
Journal | Drug and alcohol dependence |
Volume | 179 |
Publication status | Published - 1 Oct 2017 |
Peer-reviewed | Yes |
External IDs
PubMed | 28750254 |
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ORCID | /0000-0001-7646-8265/work/142232691 |
ORCID | /0000-0002-9687-5527/work/142235307 |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Alcohol dependence, Community youth, Latent class analysis, Mental disorders, Prospective-longitudinal, Risk factor