Prediction of incidence and stability of alcohol use disorders by latent internalizing psychopathology risk profiles in adolescence and young adulthood
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Background Comorbid internalizing mental disorders in alcohol use disorders (AUD) can be understood as putative independent risk factors for AUD or as expressions of underlying shared psychopathology vulnerabilities. However, it remains unclear whether: 1) specific latent internalizing psychopathology risk-profiles predict AUD-incidence and 2) specific latent internalizing comorbidity-profiles in AUD predict AUD-stability. Aims To investigate baseline latent internalizing psychopathology risk profiles as predictors of subsequent AUD-incidence and -stability in adolescents and young adults. Methods Data from the prospective-longitudinal EDSP study (baseline age 14–24 years) were used. The study-design included up to three follow-up assessments in up to ten years. DSM-IV mental disorders were assessed with the DIA-X/M-CIDI. To investigate risk-profiles and their associations with AUD-outcomes, latent class analysis with auxiliary outcome variables was applied. Results AUD-incidence: a 4-class model (N = 1683) was identified (classes: normative-male [45.9%], normative-female [44.2%], internalizing [5.3%], nicotine dependence [4.5%]). Compared to the normative-female class, all other classes were associated with a higher risk of subsequent incident alcohol dependence (p < 0.05). AUD-stability: a 3-class model (N = 1940) was identified with only one class (11.6%) with high probabilities for baseline AUD. This class was further characterized by elevated substance use disorder (SUD) probabilities and predicted any subsequent AUD (OR 8.5, 95% CI 5.4–13.3). Conclusions An internalizing vulnerability may constitute a pathway to AUD incidence in adolescence and young adulthood. In contrast, no indication for a role of internalizing comorbidity profiles in AUD-stability was found, which may indicate a limited importance of such profiles – in contrast to SUD-related profiles – in AUD stability.
Details
Originalsprache | Englisch |
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Seiten (von - bis) | 32-41 |
Seitenumfang | 10 |
Fachzeitschrift | Drug and alcohol dependence |
Jahrgang | 179 |
Publikationsstatus | Veröffentlicht - 1 Okt. 2017 |
Peer-Review-Status | Ja |
Externe IDs
PubMed | 28750254 |
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ORCID | /0000-0001-7646-8265/work/142232691 |
ORCID | /0000-0002-9687-5527/work/142235307 |
Schlagworte
Ziele für nachhaltige Entwicklung
ASJC Scopus Sachgebiete
Schlagwörter
- Alcohol dependence, Community youth, Latent class analysis, Mental disorders, Prospective-longitudinal, Risk factor