Polysialic acid expression in the salamander retina is inducible by thyroxine

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Catherina G. Becker - , University of Bremen (Author)
  • Thomas Becker - , University of Bremen (Author)
  • Andrea Schmidt - , University of Bremen (Author)
  • Gerhard Roth - , University of Bremen (Author)

Abstract

Polysialylation of the neural cell adhesion molecule (NCAM) in the retina of Pleurodeles wald is up-regulated during metamorphosis. Incubation of larvae in thyroxine permanently induced polysialic acid expression in the retina in a concentration-dependent but age-independent manner within 3 days of incubation (3 × 10-7 M). Retinoic acid had no effect. This suggests direct hormonal regulation of a post-translational modification of NCAM in the amphibian retina.

Details

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalBrain research
Volume79
Issue number1
Publication statusPublished - 13 May 1994
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 8070059

Keywords

ASJC Scopus subject areas

Keywords

  • Metamorphosis, Neural cell adhesion molecule, Paedomorphosis, Pleurodeles waltl, Retinoic acid, Thyroid hormone