Polysialic acid expression in the salamander retina is inducible by thyroxine

Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung

Beitragende

  • Catherina G. Becker - , University of Bremen (Autor:in)
  • Thomas Becker - , University of Bremen (Autor:in)
  • Andrea Schmidt - , University of Bremen (Autor:in)
  • Gerhard Roth - , University of Bremen (Autor:in)

Abstract

Polysialylation of the neural cell adhesion molecule (NCAM) in the retina of Pleurodeles wald is up-regulated during metamorphosis. Incubation of larvae in thyroxine permanently induced polysialic acid expression in the retina in a concentration-dependent but age-independent manner within 3 days of incubation (3 × 10-7 M). Retinoic acid had no effect. This suggests direct hormonal regulation of a post-translational modification of NCAM in the amphibian retina.

Details

OriginalspracheEnglisch
Seiten (von - bis)140-146
Seitenumfang7
FachzeitschriftBrain research
Jahrgang79
Ausgabenummer1
PublikationsstatusVeröffentlicht - 13 Mai 1994
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 8070059

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Metamorphosis, Neural cell adhesion molecule, Paedomorphosis, Pleurodeles waltl, Retinoic acid, Thyroid hormone