Pharmacotherapies and Aortic Heme Oxygenase-1 Expression in Patients with Abdominal Aortic Aneurysm

Research output: Contribution to journalResearch articleInvitedpeer-review

Contributors

  • Anja Hofmann - , Department of Visceral, Thoracic and Vascular Surgery (First author)
  • Bianca Hamann - , University Hospital Carl Gustav Carus Dresden (Author)
  • Anna Klimova - , National Center for Tumor Diseases (NCT) Dresden (Author)
  • Margarete Müglich - (Author)
  • Steffen Wolk - (Author)
  • Albert Busch - (Author)
  • Frieda Frank - (Author)
  • Pamela Sabarstinski - (Author)
  • Marvin Kapalla - (Author)
  • Josef Albin Nees - (Author)
  • Coy Brunssen - (Author)
  • David M. Poitz - (Author)
  • Henning Morawietz - (Author)
  • Christian Reeps - , University Hospital Carl Gustav Carus Dresden (Last author)

Abstract

Background: Treatment of cardiovascular risk factors slows the progression of small abdominal aortic aneurysms (AAA). Heme oxygenase-1 (HO-1) is a stress- and hemin-induced enzyme providing cytoprotection against oxidative stress when overexpressed. However, nothing is known about the effects of cardiometabolic standard therapies on HO-1 expression in aortic walls in patients with end-stage AAA. Methods: The effects of statins, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), beta-blockers, diuretics, acetylsalicylic acid (ASA), and therapeutic anticoagulation on HO-1 mRNA and protein expressions were analyzed in AAA patients using multivariate logistic regression analysis and comparison of monotherapy. Results: Analysis of monotherapy revealed that HO-1 mRNA and protein expressions were higher in patients on diuretics and lower in patients on statin therapy. Tests on combinations of antihypertensive medications demonstrated that ACE inhibitors and diuretics, ARBs and diuretics, and beta-blockers and diuretics were associated with increase in HO-1 mRNA expression. ASA and therapeutic anticoagulation were not linked to HO-1 expression. Conclusion: Diuretics showed the strongest association with HO-1 expression, persisting even in combination with other antihypertensive medications. Hence, changes in aortic HO-1 expression in response to different medical therapies and their effects on vessel wall degeneration should be analyzed in future studies.

Details

Original languageEnglish
JournalAntioxidants
Volume2022
Issue number11
Publication statusPublished - 2022
Peer-reviewedYes

External IDs

Scopus 85138511720

Keywords

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