Pharmacotherapies and Aortic Heme Oxygenase-1 Expression in Patients with Abdominal Aortic Aneurysm

Publikation: Beitrag in FachzeitschriftForschungsartikelEingeladenBegutachtung

Beitragende

  • Anja Hofmann - , Klinik und Poliklinik für Viszeral-, Thorax- und Gefäßchirurgie (Erstautor:in)
  • Bianca Hamann - , Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Anna Klimova - , Nationales Zentrum für Tumorerkrankungen (NCT) Dresden (Autor:in)
  • Margarete Müglich - (Autor:in)
  • Steffen Wolk - (Autor:in)
  • Albert Busch - (Autor:in)
  • Frieda Frank - (Autor:in)
  • Pamela Sabarstinski - (Autor:in)
  • Marvin Kapalla - (Autor:in)
  • Josef Albin Nees - (Autor:in)
  • Coy Brunssen - (Autor:in)
  • David M. Poitz - (Autor:in)
  • Henning Morawietz - (Autor:in)
  • Christian Reeps - , Universitätsklinikum Carl Gustav Carus Dresden (Letztautor:in)

Abstract

Background: Treatment of cardiovascular risk factors slows the progression of small abdominal aortic aneurysms (AAA). Heme oxygenase-1 (HO-1) is a stress- and hemin-induced enzyme providing cytoprotection against oxidative stress when overexpressed. However, nothing is known about the effects of cardiometabolic standard therapies on HO-1 expression in aortic walls in patients with end-stage AAA. Methods: The effects of statins, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), beta-blockers, diuretics, acetylsalicylic acid (ASA), and therapeutic anticoagulation on HO-1 mRNA and protein expressions were analyzed in AAA patients using multivariate logistic regression analysis and comparison of monotherapy. Results: Analysis of monotherapy revealed that HO-1 mRNA and protein expressions were higher in patients on diuretics and lower in patients on statin therapy. Tests on combinations of antihypertensive medications demonstrated that ACE inhibitors and diuretics, ARBs and diuretics, and beta-blockers and diuretics were associated with increase in HO-1 mRNA expression. ASA and therapeutic anticoagulation were not linked to HO-1 expression. Conclusion: Diuretics showed the strongest association with HO-1 expression, persisting even in combination with other antihypertensive medications. Hence, changes in aortic HO-1 expression in response to different medical therapies and their effects on vessel wall degeneration should be analyzed in future studies.
Titel in Übersetzung
Medikamentöse Therapie und Hämoxygenase-1 Expression in Patienten mit einem abdominellen Aortenaneurysma

Details

OriginalspracheEnglisch
FachzeitschriftAntioxidants
Jahrgang2022
Ausgabenummer11
PublikationsstatusVeröffentlicht - 2022
Peer-Review-StatusJa

Externe IDs

Scopus 85138511720

Schlagworte

DFG-Fachsystematik nach Fachkollegium

Fächergruppen, Lehr- und Forschungsbereiche, Fachgebiete nach Destatis

ASJC Scopus Sachgebiete