Osteoclast and osteoblast response to strontiumdoped struvite coatings on titanium for improved bone integration
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
To develop implants with improved bone ingrowth, titanium substrates were coated with homogeneous and dense struvite (MgNH4PO4.6H2O) layers by means of electrochemically assisted deposition. Strontium nitrate was added to the coating electrolyte in various concentrations, in order to fabricate Sr-doped struvite coatings with Sr loading ranging from 10.6 to 115 μg/cm2. It was expected and observed that osteoclast activity surrounding the implantwas inhibited. The cytocompatibility of the coatings and the effect of Sr-ions in different concentrations on osteoclast formation were analyzed in vitro. Osteoclast differentiation was elucidated on morphological, biochemical as well as on gene expression level. It could be shown that moderate concentrations of Sr2+had an inhibitory effect on osteoclast formation, while the growth of osteoblastic cells was not negatively influenced compared to pure struvite surfaces. In summary, the electrochemically deposited Sr-doped struvite coatings are a promising approach to improve bone implant ingrowth.
Details
Original language | English |
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Pages (from-to) | 631-641 |
Number of pages | 11 |
Journal | Biomedical engineering : joint journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering |
Volume | 65 |
Issue number | 5 |
Publication status | Published - 1 Oct 2020 |
Peer-reviewed | Yes |
External IDs
PubMed | 32452822 |
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ORCID | /0000-0001-9509-6145/work/145224971 |
Keywords
ASJC Scopus subject areas
Keywords
- Bone implant, Electrochemically assisted deposition, Magnesium phosphate cement, Osteoclast differentiation