Osteoclast and osteoblast response to strontiumdoped struvite coatings on titanium for improved bone integration

Research output: Contribution to journalResearch articleContributedpeer-review


  • Claus Moseke - , University of Applied Sciences Mittelhessen (Author)
  • Katharina Wimmer - , University of Würzburg (Author)
  • Markus Meininger - , University of Würzburg (Author)
  • Julia Zerweck - , University of Würzburg (Author)
  • Cornelia Wolf-Brandstetter - , Chair of Biomaterials, Max Bergmann Center of Biomaterials Dresden, TUD Dresden University of Technology (Author)
  • Uwe Gbureck - , University of Würzburg (Author)
  • Andrea Ewald - , University of Würzburg (Author)


To develop implants with improved bone ingrowth, titanium substrates were coated with homogeneous and dense struvite (MgNH4PO4.6H2O) layers by means of electrochemically assisted deposition. Strontium nitrate was added to the coating electrolyte in various concentrations, in order to fabricate Sr-doped struvite coatings with Sr loading ranging from 10.6 to 115 μg/cm2. It was expected and observed that osteoclast activity surrounding the implantwas inhibited. The cytocompatibility of the coatings and the effect of Sr-ions in different concentrations on osteoclast formation were analyzed in vitro. Osteoclast differentiation was elucidated on morphological, biochemical as well as on gene expression level. It could be shown that moderate concentrations of Sr2+had an inhibitory effect on osteoclast formation, while the growth of osteoblastic cells was not negatively influenced compared to pure struvite surfaces. In summary, the electrochemically deposited Sr-doped struvite coatings are a promising approach to improve bone implant ingrowth.


Original languageEnglish
Pages (from-to)631-641
Number of pages11
JournalBiomedizinische Technik
Issue number5
Publication statusPublished - 1 Oct 2020

External IDs

PubMed 32452822
ORCID /0000-0001-9509-6145/work/145224971


ASJC Scopus subject areas


  • Bone implant, Electrochemically assisted deposition, Magnesium phosphate cement, Osteoclast differentiation