Osteoclast and osteoblast response to strontiumdoped struvite coatings on titanium for improved bone integration

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Claus Moseke - , University of Applied Sciences Mittelhessen (Autor:in)
  • Katharina Wimmer - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Markus Meininger - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Julia Zerweck - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Cornelia Wolf-Brandstetter - , Professur für Biomaterialien, Max Bergmann Zentrum für Biomaterialien Dresden (MBZ), Technische Universität Dresden (Autor:in)
  • Uwe Gbureck - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Andrea Ewald - , Julius-Maximilians-Universität Würzburg (Autor:in)

Abstract

To develop implants with improved bone ingrowth, titanium substrates were coated with homogeneous and dense struvite (MgNH4PO4.6H2O) layers by means of electrochemically assisted deposition. Strontium nitrate was added to the coating electrolyte in various concentrations, in order to fabricate Sr-doped struvite coatings with Sr loading ranging from 10.6 to 115 μg/cm2. It was expected and observed that osteoclast activity surrounding the implantwas inhibited. The cytocompatibility of the coatings and the effect of Sr-ions in different concentrations on osteoclast formation were analyzed in vitro. Osteoclast differentiation was elucidated on morphological, biochemical as well as on gene expression level. It could be shown that moderate concentrations of Sr2+had an inhibitory effect on osteoclast formation, while the growth of osteoblastic cells was not negatively influenced compared to pure struvite surfaces. In summary, the electrochemically deposited Sr-doped struvite coatings are a promising approach to improve bone implant ingrowth.

Details

OriginalspracheEnglisch
Seiten (von - bis)631-641
Seitenumfang11
FachzeitschriftBiomedizinische Technik
Jahrgang65
Ausgabenummer5
PublikationsstatusVeröffentlicht - 1 Okt. 2020
Peer-Review-StatusJa

Externe IDs

PubMed 32452822
ORCID /0000-0001-9509-6145/work/145224971

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Bone implant, Electrochemically assisted deposition, Magnesium phosphate cement, Osteoclast differentiation