Novel genetic loci underlying human intracranial volume identified through genome-wide association

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Hieab H.H. Adams - , Erasmus University Rotterdam (Author)
  • Derrek P. Hibar - , Keck School of Medicine at University of Southern California (Author)
  • Vincent Chouraki - , Boston University, Université de Lille, National Institutes of Health (NIH) (Author)
  • Jason L. Stein - , Keck School of Medicine at University of Southern California, University of North Carolina at Chapel Hill (Author)
  • Paul A. Nyquist - , Johns Hopkins Medicine (Author)
  • Miguel E. Rentería - , Queensland Institute of Medical Research (Author)
  • Stella Trompet - , Leiden University (Author)
  • Alejandro Arias-Vasquez - , Radboud University Nijmegen (Author)
  • Sudha Seshadri - , Boston University, National Institutes of Health (NIH) (Author)
  • Sylvane Desrivières - , King's College London (KCL) (Author)
  • Ashley H. Beecham - , University of Miami Miller School of Medicine (Author)
  • Neda Jahanshad - , Keck School of Medicine at University of Southern California (Author)
  • Katharina Wittfeld - , German Center for Neurodegenerative Diseases (DZNE), University of Greifswald (Author)
  • Sven J. Van Der Lee - , Erasmus University Rotterdam (Author)
  • Lucija Abramovic - , Utrecht University (Author)
  • Saud Alhusaini - , McGill University Health Centre, Royal College of Surgeons in Ireland (Author)
  • Najaf Amin - , Erasmus University Rotterdam (Author)
  • Micael Andersson - , Umeå University (Author)
  • Konstantinos Arfanakis - , Illinois Institute of Technology, Rush University (Author)
  • Benjamin S. Aribisala - , University of Edinburgh, Lagos State University (Author)
  • Nicola J. Armstrong - , University of New South Wales, Murdoch University (Author)
  • Lavinia Athanasiu - , University of Oslo (Author)
  • Tomas Axelsson - , Uppsala University (Author)
  • Alexa Beiser - , Boston University, National Institutes of Health (NIH) (Author)
  • Manon Bernard - , University of Toronto (Author)
  • Joshua C. Bis - , University of Washington (Author)
  • Laura M.E. Blanken - , Erasmus University Rotterdam (Author)
  • Susan H. Blanton - , University of Miami Miller School of Medicine (Author)
  • Marc M. Bohlken - , Utrecht University (Author)
  • Marco P. Boks - , Utrecht University (Author)
  • Janita Bralten - , Radboud University Nijmegen (Author)
  • Adam M. Brickman - , Columbia University (Author)
  • Owen Carmichael - , LSU Pennington Biomedical Research Center (Author)
  • M. Mallar Chakravarty - , McGill University (Author)
  • Ganesh Chauhan - , Université de Bordeaux (Author)
  • Qiang Chen - , Lieber Institute for Brain Development (Author)
  • Christopher R.K. Ching - , Keck School of Medicine at University of Southern California, University of California at Los Angeles (Author)
  • Gabriel Cuellar-Partida - , Queensland Institute of Medical Research (Author)
  • Anouk Den Braber - , Vrije Universiteit Amsterdam (VU) (Author)
  • Nhat Trung Doan - , University of Oslo (Author)
  • Stefan Ehrlich - , Division of Psychological and Social Medicine and Developmental Neurosciences, Massachusetts General Hospital (Author)
  • Irina Filippi - , Université Paris-Saclay, Université Paris Cité (Author)
  • Tian Ge - , Massachusetts General Hospital, Harvard University, Broad Institute of Harvard University and MIT (Author)
  • Sudheer Giddaluru - , University of Bergen (Author)
  • Aaron L. Goldman - , Lieber Institute for Brain Development (Author)
  • Rebecca F. Gottesman - , Johns Hopkins Medicine (Author)
  • Corina U. Greven - , Radboud University Nijmegen, King's College London (KCL) (Author)
  • Oliver Grimm - , Heidelberg University  (Author)
  • Michael E. Griswold - , University of Mississippi (Author)
  • Tulio Guadalupe - , Max Planck Institute for Psycholinguistics, Radboud University Nijmegen (Author)
  • Johanna Hass - , Medical Faculty Carl Gustav Carus (Author)
  • Unn K. Haukvik - , University of Oslo, Diakonhjemmet Hospital (Author)
  • Saima Hilal - , National University of Singapore, MOH Holdings Pte Ltd. (Author)
  • Edith Hofer - , Medical University of Graz (Author)
  • David Hoehn - , Max Planck Institute of Psychiatry (Author)
  • Avram J. Holmes - , Massachusetts General Hospital, Yale University (Author)
  • Martine Hoogman - , Radboud University Nijmegen (Author)
  • Deborah Janowitz - , University of Greifswald (Author)
  • Tianye Jia - , King's College London (KCL) (Author)
  • Dalia Kasperaviciute - , Epilepsy Society, Imperial College London (Author)
  • Sungeun Kim - , Indiana University-Purdue University Indianapolis (Author)
  • Marieke Klein - , Radboud University Nijmegen (Author)
  • Bernd Kraemer - , Heidelberg University  (Author)
  • Phil H. Lee - , Massachusetts General Hospital, Harvard University, Broad Institute of Harvard University and MIT (Author)
  • Jiemin Liao - , Singapore National Eye Center (Author)
  • David C.M. Liewald - , University of Edinburgh (Author)
  • Lorna M. Lopez - , University of Edinburgh (Author)
  • Michelle Luciano - , University of Edinburgh (Author)
  • Christine Macare - , King's College London (KCL) (Author)
  • Andre Marquand - , Radboud University Nijmegen (Author)
  • Mar Matarin - , Epilepsy Society, University College London (Author)
  • Karen A. Mather - , University of New South Wales (Author)
  • Manuel Mattheisen - , Aarhus University, H. Lundbeck A/S (Author)
  • Bernard Mazoyer - , Université de Bordeaux (Author)
  • David R. McKay - , Yale University, Olin Neuropsychiatric Research Center (Author)
  • Rebekah McWhirter - , University of Tasmania (Author)
  • Yuri Milaneschi - , Vrije Universiteit Amsterdam (VU) (Author)
  • Nazanin Mirza-Schreiber - , Max Planck Institute of Psychiatry (Author)
  • Ryan L. Muetzel - , Erasmus University Rotterdam (Author)
  • Susana Muñoz Maniega - , University of Edinburgh (Author)
  • Kwangsik Nho - , Indiana University-Purdue University Indianapolis (Author)
  • Allison C. Nugent - , National Institutes of Health (NIH) (Author)
  • Loes M.Olde Loohuis - , University of California at Los Angeles (Author)
  • Jaap Oosterlaan - , Vrije Universiteit Amsterdam (VU) (Author)
  • Martina Papmeyer - , University of Edinburgh, University of Bern (Author)
  • Irene Pappa - , Erasmus University Rotterdam (Author)
  • Lukas Pirpamer - , Medical University of Graz (Author)
  • Sara Pudas - , Umeå University (Author)
  • Benno Pütz - , Max Planck Institute of Psychiatry (Author)
  • Kumar B. Rajan - , Rush University (Author)
  • Adaikalavan Ramasamy - , University College London, King's College London (KCL), University of Oxford (Author)
  • Jennifer S. Richards - , Radboud University Nijmegen (Author)
  • Shannon L. Risacher - , Indiana University-Purdue University Indianapolis (Author)
  • Roberto Roiz-Santiañez - , Hospital Universitario Marques de Valdecilla, CIBER - Center for Biomedical Research Network (Author)
  • Nanda Rommelse - , Radboud University Nijmegen (Author)
  • Emma J. Rose - , Trinity College Dublin (Author)
  • Natalie A. Royle - , University of Edinburgh (Author)
  • Tatjana Rundek - , University of Miami Miller School of Medicine (Author)
  • Philipp G. Sämann - , Max Planck Institute of Psychiatry (Author)
  • Claudia L. Satizabal - , Boston University (Author)
  • Lianne Schmaal - , National Institutes of Health (NIH) (Author)
  • Andrew J. Schork - , ORYGEN Youth Health, University of Melbourne, Vrije Universiteit Amsterdam (VU) (Author)
  • Li Shen - , University of California at San Diego (Author)
  • Jean Shin - , Indiana University-Purdue University Indianapolis (Author)
  • Elena Shumskaya - , University of Toronto (Author)
  • Albert V. Smith - , Radboud University Nijmegen (Author)
  • Emma Sprooten - , Icelandic Heart Association, University of Iceland (Author)
  • Lachlan T. Strike - , Yale University, Olin Neuropsychiatric Research Center, University of Edinburgh, Icahn School of Medicine at Mount Sinai (Author)
  • Alexander Teumer - , Queensland Institute of Medical Research, University of Queensland (Author)
  • Russell Thomson - , University of Greifswald (Author)
  • Diana Tordesillas-Gutierrez - , Western Sydney University (Author)
  • Roberto Toro - , CIBER - Center for Biomedical Research Network, Marqués de Valdecilla Research Institute (IDIVAL) (Author)
  • Daniah Trabzuni - , Institut Pasteur Paris (Author)
  • Dhananjay Vaidya - , University College London, King Faisal Specialist Hospital and Research Centre (Author)
  • Jeroen Van Der Grond - , Johns Hopkins Medicine (Author)
  • Dennis Van Der Meer - , Leiden University (Author)
  • Marjolein M.J. Van Donkelaar - , University of Groningen (Author)
  • Kristel R. Van Eijk - , Radboud University Nijmegen (Author)
  • Theo G.M. Van Erp - , Utrecht University (Author)
  • Daan Van Rooij - , University of California at Irvine (Author)
  • Esther Walton - , Radboud University Nijmegen, University of Groningen (Author)
  • Lars T. Westlye - , Medical Faculty Carl Gustav Carus (Author)
  • Christopher D. Whelan - , University of Oslo (Author)
  • Beverly G. Windham - , Keck School of Medicine at University of Southern California, Royal College of Surgeons in Ireland (Author)
  • Anderson M. Winkler - , University of Mississippi (Author)
  • Girma Woldehawariat - , Yale University, National Institutes of Health (NIH), University of Oxford (Author)
  • Christiane Wolf - , University of Würzburg (Author)
  • Thomas Wolfers - , Radboud University Nijmegen (Author)
  • Bing Xu - , King's College London (KCL) (Author)
  • Lisa R. Yanek - , Johns Hopkins Medicine (Author)
  • Jingyun Yang - , Rush University (Author)
  • Alex Zijdenbos - , University of Montreal (Author)
  • Marcel P. Zwiers - , Radboud University Nijmegen (Author)
  • Ingrid Agartz - , University of Oslo, Diakonhjemmet Hospital, Karolinska Institutet (Author)
  • Neelum T. Aggarwal - , Rush University (Author)
  • Laura Almasy - , University of Texas Rio Grande Valley School of Medicine, University of Pennsylvania (Author)
  • David Ames - , Royal Melbourne Hospital, University of Melbourne (Author)
  • Philippe Amouyel - , Université de Lille (Author)
  • Ole A. Andreassen - , University of Oslo (Author)
  • Sampath Arepalli - , National Institutes of Health (NIH) (Author)
  • Amelia A. Assareh - , University of New South Wales (Author)
  • Sandra Barral - , Columbia University (Author)
  • Mark E. Bastin - , University of Edinburgh (Author)
  • Diane M. Becker - , Johns Hopkins Medicine (Author)
  • James T. Becker - , University of Pittsburgh (Author)
  • David A. Bennett - , Rush University (Author)
  • John Blangero - , University of Texas Rio Grande Valley School of Medicine (Author)
  • Hans Van Bokhoven - , Radboud University Nijmegen (Author)
  • Dorret I. Boomsma - , Vrije Universiteit Amsterdam (VU) (Author)
  • Henry Brodaty - , University of New South Wales (Author)
  • Rachel M. Brouwer - , Utrecht University (Author)
  • Han G. Brunner - , Radboud University Nijmegen, Maastricht University Medical Centre (UMC+) (Author)
  • Randy L. Buckner - , Massachusetts General Hospital, Harvard University (Author)
  • Jan K. Buitelaar - , Radboud University Nijmegen (Author)
  • Kazima B. Bulayeva - , Dagestan State University (Author)
  • Wiepke Cahn - , Utrecht University (Author)
  • Vince D. Calhoun - , The Mind Research Network, University of New Mexico (Author)
  • Dara M. Cannon - , National Institutes of Health (NIH), University of Galway (Author)
  • Gianpiero L. Cavalleri - , Royal College of Surgeons in Ireland (Author)
  • Christopher Chen - , National University of Singapore, MOH Holdings Pte Ltd. (Author)
  • Ching Yu Cheng - , Singapore National Eye Center, Duke-NUS Medical School, National University of Singapore (Author)
  • Sven Cichon - , University of Basel, University of Bonn, Jülich Research Centre (Author)
  • Mark R. Cookson - , National Institutes of Health (NIH) (Author)
  • Aiden Corvin - , Trinity College Dublin (Author)
  • Benedicto Crespo-Facorro - , Hospital Universitario Marques de Valdecilla, CIBER - Center for Biomedical Research Network (Author)
  • Joanne E. Curran - , University of Texas Rio Grande Valley School of Medicine (Author)
  • Michael Czisch - , Max Planck Institute of Psychiatry (Author)
  • Anders M. Dale - , University of California at San Diego (Author)
  • Gareth E. Davies - , Harvard University, Avera Health, Broad Institute of Harvard University and MIT (Author)
  • Eco J.C. De Geus - , Vrije Universiteit Amsterdam (VU) (Author)
  • Philip L. De Jager - , Harvard University, Broad Institute of Harvard University and MIT, Queensland University of Technology (Author)
  • Greig I. De Zubicaray - , Royal College of Surgeons in Ireland (Author)
  • Norman Delanty - , Royal College of Surgeons in Ireland, Université libre de Bruxelles (ULB) (Author)
  • Chantal Depondt - , University of Oslo (Author)
  • Anita L. Destefano - , National Institutes of Health (NIH), University of Bergen (Author)
  • Allissa Dillman - , National Institutes of Health (NIH) (Author)
  • Srdjan Djurovic - , University of Bergen, University of Galway (Author)
  • Gary Donohoe - , Trinity College Dublin, Johnson & Johnson (Author)
  • Wayne C. Drevets - , National Institutes of Health (NIH), Charité – Universitätsmedizin Berlin (Author)
  • Ravi Duggirala - , University of Texas Rio Grande Valley School of Medicine (Author)
  • Thomas D. Dyer - , University of Texas Rio Grande Valley School of Medicine (Author)
  • Susanne Erk - , National Institutes of Health (NIH) (Author)
  • Thomas Espeseth - , University of Oslo (Author)
  • Denis A. Evans - , Rush University (Author)
  • Iryna O. Fedko - , Vrije Universiteit Amsterdam (VU) (Author)
  • Guillén Fernández - , Radboud University Nijmegen (Author)
  • Luigi Ferrucci - , Rush University (Author)
  • Simon E. Fisher - , Radboud University Nijmegen, Max Planck Institute for Psycholinguistics (Author)
  • Debra A. Fleischman - , Rush University, University of Glasgow, Indiana University-Purdue University Indianapolis (Author)
  • Ian Ford - , University of Texas Health Science Center at San Antonio (Author)
  • Tatiana M. Foroud - , Indiana University-Purdue University Indianapolis, National Institutes of Natural Sciences - National Institute for Physiological Sciences (Author)
  • Peter T. Fox - , Harvard University (Author)
  • Clyde Francks - , Radboud University Nijmegen, Max Planck Institute for Psycholinguistics (Author)
  • Masaki Fukunaga - , Osaka University (Author)
  • J. Raphael Gibbs - , University College London, National Institutes of Health (NIH) (Author)
  • David C. Glahn - , Yale University, Olin Neuropsychiatric Research Center (Author)
  • Randy L. Gollub - , Massachusetts General Hospital, Harvard University (Author)
  • Harald H.H. Göring - , University of Texas Rio Grande Valley School of Medicine (Author)
  • Hans J. Grabe - , University of Greifswald (Author)
  • Robert C. Green - , Harvard University, Osaka University (Author)
  • Oliver Gruber - , Heidelberg University  (Author)
  • Vilmundur Gudnason - , Icelandic Heart Association, University of Iceland (Author)
  • Sebastian Guelfi - , University College London (Author)
  • Narelle K. Hansell - , Queensland Institute of Medical Research, University of Queensland (Author)
  • John Hardy - , University College London (Author)
  • Catharina A. Hartman - , University of Groningen (Author)
  • Ryota Hashimoto - , University of Greifswald, German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Katrin Hegenscheid - , Vrije Universiteit Amsterdam (VU) (Author)
  • Andreas Heinz - , Charité – Universitätsmedizin Berlin (Author)
  • Stephanie Le Hellard - , University of Bergen (Author)
  • Dena G. Hernandez - , University College London, National Institutes of Health (NIH), University of Iowa (Author)
  • Dirk J. Heslenfeld - , HMNC Brain Health (Author)
  • Beng Choon Ho - , University of Greifswald (Author)
  • Pieter J. Hoekstra - , University of Groningen (Author)
  • Wolfgang Hoffmann - , German Center for Neurodegenerative Diseases (DZNE), University of Greifswald (Author)
  • Albert Hofman - , Erasmus University Rotterdam (Author)
  • Florian Holsboer - , Max Planck Institute of Psychiatry, Fujita Health University (Author)
  • Georg Homuth - , Mayo Clinic Rochester, MN (Author)
  • Norbert Hosten - , Vrije Universiteit Amsterdam (VU) (Author)
  • Jouke Jan Hottenga - , Vrije Universiteit Amsterdam (VU) (Author)
  • Hilleke E.Hulshoff Pol - , Utrecht University (Author)
  • Masashi Ikeda - , University of Maryland, Baltimore (Author)
  • M. Kamran Ikram - , Erasmus University Rotterdam, National University of Singapore, MOH Holdings Pte Ltd., Singapore National Eye Center, Duke-NUS Medical School (Author)
  • Clifford R. Jack - , University of Sussex (Author)
  • Mark Jenkinson - , University of Oxford (Author)
  • Robert Johnson - , University College London (Author)
  • Erik G. Jönsson - , University of Oslo, University of Oxford (Author)
  • J. Wouter Jukema - , Leiden University (Author)
  • René S. Kahn - , Utrecht University (Author)
  • Ryota Kanai - , Araya Inc., Medical University of Łódź, Mayo Clinic Rochester, MN (Author)
  • Iwona Kloszewska - , University of Maryland, Baltimore (Author)
  • David S. Knopman - , Neuroscience Research Australia (Author)
  • Peter Kochunov - , University of New South Wales (Author)
  • John B. Kwok - , Columbia University, National Institutes of Health (NIH) (Author)
  • Stephen M. Lawrie - , University of Edinburgh (Author)
  • Hervé Lemaître - , Université Paris-Saclay, Université Paris Cité (Author)
  • Xinmin Liu - , National Institutes of Health (NIH), University of Washington (Author)
  • Dan L. Longo - , University of Washington (Author)
  • W. T. Longstreth - , University of Pittsburgh (Author)
  • Oscar L. Lopez - , University of Oxford, King's College London (KCL) (Author)
  • Simon Lovestone - , University of California at Davis, Johns Hopkins Medicine (Author)
  • Oliver Martinez - , University of Queensland (Author)
  • Jean Luc Martinot - , Université Paris-Saclay, Université Paris Cité (Author)
  • Venkata S. Mattay - , Lieber Institute for Brain Development, Johns Hopkins Medicine, University of Perugia (Author)
  • Colm McDonald - , University of Galway (Author)
  • Andrew M. McIntosh - , University of Edinburgh (Author)
  • Katie L. McMahon - , Munich Cluster for Systems Neurology (SyNergy) (Author)
  • Francis J. McMahon - , National Institutes of Health (NIH) (Author)
  • Patrizia Mecocci - , University of Liverpool (UOL) (Author)
  • Ingrid Melle - , University of Oslo (Author)
  • Andreas Meyer-Lindenberg - , Heidelberg University  (Author)
  • Sebastian Mohnke - , National Institutes of Health (NIH) (Author)
  • Grant W. Montgomery - , Queensland Institute of Medical Research (Author)
  • Derek W. Morris - , Trinity College Dublin, Johnson & Johnson (Author)
  • Thomas H. Mosley - , University of Mississippi (Author)
  • Thomas W. Mühleisen - , University of Galway, Jülich Research Centre (Author)
  • Bertram Müller-Myhsok - , Max Planck Institute of Psychiatry, University of Greifswald, Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) (Author)
  • Michael A. Nalls - , National Institutes of Health (NIH) (Author)
  • Matthias Nauck - , University of Warwick, Erasmus University Rotterdam (Author)
  • Thomas E. Nichols - , University of Oxford, Delft University of Technology (Author)
  • Wiro J. Niessen - , Erasmus University Rotterdam, University of Bonn, University of Toronto (Author)
  • Markus M. Nöthen - , University of Bonn, University of Toronto (Author)
  • Lars Nyberg - , Umeå University (Author)
  • Kazutaka Ohi - , University of Greifswald (Author)
  • Rene L. Olvera - , Harvard University (Author)
  • Roel A. Ophoff - , Utrecht University, University of California at Los Angeles (Author)
  • Massimo Pandolfo - , University of Oslo (Author)
  • Tomas Paus - , Child Mind Institute, Inc., University of Toronto (Author)
  • Zdenka Pausova - , University of Toronto, University of Calgary (Author)
  • Brenda W.J.H. Penninx - , Vrije Universiteit Amsterdam (VU) (Author)
  • G. Bruce Pike - , University of Washington (Author)
  • Steven G. Potkin - , University of California at Irvine (Author)
  • Bruce M. Psaty - , University of Pittsburgh, Group Health Cooperative, University of New South Wales, University of California at Los Angeles, University of Miami Miller School of Medicine (Author)
  • Simone Reppermund - , University of New South Wales, Prince of Wales Hospital (Author)
  • Marcella Rietschel - , Heidelberg University  (Author)
  • Joshua L. Roffman - , Massachusetts General Hospital (Author)
  • Nina Romanczuk-Seiferth - , National Institutes of Health (NIH) (Author)
  • Jerome I. Rotter - , King's College London (KCL) (Author)
  • Mina Ryten - , University College London, King's College London (KCL) (Author)
  • Ralph L. Sacco - , University of Miami Miller School of Medicine, King's College London (KCL) (Author)
  • Perminder S. Sachdev - , University of New South Wales, NIHR Maudsley Biomedical Research Centre (BRC) (Author)
  • Andrew J. Saykin - , Indiana University-Purdue University Indianapolis, National Institutes of Natural Sciences - National Institute for Physiological Sciences (Author)
  • Reinhold Schmidt - , Medical University of Graz (Author)
  • Peter R. Schofield - , Columbia University, National Institutes of Health (NIH) (Author)
  • Sigurdur Sigurdsson - , Icelandic Heart Association (Author)
  • Andy Simmons - , Royal College of Surgeons in Ireland, Uppsala University, University of Eastern Finland (Author)
  • Andrew Singleton - , National Institutes of Health (NIH) (Author)
  • Sanjay M. Sisodiya - , Epilepsy Society (Author)
  • Colin Smith - , Monash University (Author)
  • Jordan W. Smoller - , Massachusetts General Hospital, Harvard University, Broad Institute of Harvard University and MIT (Author)
  • Hilkka Soininen - , University of Glasgow, Keck School of Medicine at University of Southern California (Author)
  • Velandai Srikanth - , Johns Hopkins University (Author)
  • Vidar M. Steen - , University of Bergen (Author)
  • David J. Stott - , Georgia State University (Author)
  • Jessika E. Sussmann - , University of Edinburgh (Author)
  • Anbupalam Thalamuthu - , University of New South Wales (Author)
  • Henning Tiemeier - , Erasmus University Rotterdam (Author)
  • Arthur W. Toga - , Université de Bordeaux (Author)
  • Bryan J. Traynor - , National Institutes of Health (NIH) (Author)
  • Juan Troncoso - , Erasmus University Rotterdam (Author)
  • Jessica A. Turner - , Genentech Incorporated (Author)
  • Christophe Tzourio - , Leiden University (Author)
  • Andre G. Uitterlinden - , Erasmus University Rotterdam, University of Groningen (Author)
  • Maria C.Valdés Hernández - , University of Edinburgh (Author)
  • Marcel Van Der Brug - , University of Iowa (Author)
  • Aad Van Der Lugt - , Erasmus University Rotterdam (Author)
  • Nic J.A. Van Der Wee - , Johns Hopkins Medicine (Author)
  • Cornelia M. Van Duijn - , Erasmus University Rotterdam (Author)
  • Neeltje E.M. Van Haren - , Utrecht University (Author)
  • Dennis Van't Ent - , Vrije Universiteit Amsterdam (VU), University of Edinburgh (Author)
  • Marie Jose Van Tol - , University of California at San Francisco (Author)
  • Badri N. Vardarajan - , Columbia University (Author)
  • Dick J. Veltman - , Vrije Universiteit Amsterdam (VU) (Author)
  • Meike W. Vernooij - , Erasmus University Rotterdam (Author)
  • Henry Völzke - , University of Greifswald (Author)
  • Henrik Walter - , National Institutes of Health (NIH) (Author)
  • Joanna M. Wardlaw - , University of Edinburgh (Author)
  • Thomas H. Wassink - , Karolinska Institutet (Author)
  • Michael E. Weale - , King's College London (KCL) (Author)
  • Daniel R. Weinberger - , Lieber Institute for Brain Development, National Institutes of Health (NIH) (Author)
  • Michael W. Weiner - , Medical University of Graz (Author)
  • Wei Wen - , University of New South Wales (Author)
  • Eric Westman - , Leiden University (Author)
  • Tonya White - , Erasmus University Rotterdam (Author)
  • Tien Y. Wong - , Singapore National Eye Center, Dagestan State University, National University of Singapore (Author)
  • Clinton B. Wright - , University of Miami Miller School of Medicine, King's College London (KCL) (Author)
  • H. Ronald Zielke - , University College London (Author)
  • Alan B. Zonderman - , National Institutes of Health (NIH) (Author)
  • Ian J. Deary - , Radboud University Nijmegen (Author)
  • Charles Decarli - , University of Queensland (Author)
  • Helena Schmidt - , University of Texas Health Science Center at Houston (Author)
  • Nicholas G. Martin - , Queensland Institute of Medical Research (Author)
  • Anton J.M. De Craen - , Regional Centre for Prevention of Healthcare Associated Infections (Author)
  • Margaret J. Wright - , University of Queensland, Munich Cluster for Systems Neurology (SyNergy) (Author)
  • Lenore J. Launer - , Erasmus University Rotterdam (Author)
  • Gunter Schumann - , King's College London (KCL) (Author)
  • Myriam Fornage - , Regional Centre for Prevention of Healthcare Associated Infections (Author)
  • Barbara Franke - , Radboud University Nijmegen (Author)
  • Stéphanie Debette - , Boston University, Lieber Institute for Brain Development, Regional Centre for Prevention of Healthcare Associated Infections (Author)
  • Sarah E. Medland - , Queensland Institute of Medical Research (Author)
  • M. Arfan Ikram - , Erasmus University Rotterdam (Author)
  • Paul M. Thompson - , Keck School of Medicine at University of Southern California (Author)

Abstract

Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (genetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (N combined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits.

Details

Original languageEnglish
Pages (from-to)1569-1582
Number of pages14
JournalNature Neuroscience
Volume19
Issue number12
Publication statusPublished - 1 Dec 2016
Peer-reviewedYes

External IDs

researchoutputwizard legacy.publication#72961
Scopus 84989867010
PubMed 27694991
ORCID /0000-0003-2132-4445/work/159605877

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

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