Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
We analyze the motion of colloids propelled by a comet-like tail of polymerizing actin filaments. The curvature of the particle trajectories deviates strongly from a Gaussian distribution, implying that the underlying microscopic processes are fluctuating in a non-independent manner. Trajectories for beads of different size all showed the same non-Gaussian behavior, while the mean curvature decreased weakly with size. A stochastic simulation that includes nucleation, force-dependent dissociation, growth, and capping of filaments, shows that the non-Gaussian curvature distribution can be explained by a positive feedback mechanism in which attached chains under higher tension are more likely to snap.
Details
Original language | English |
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Pages (from-to) | 1361-1366 |
Number of pages | 6 |
Journal | European biophysics journal : with biophysics letters |
Volume | 37 |
Issue number | 8 |
Publication status | Published - Oct 2008 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 18491086 |
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Keywords
ASJC Scopus subject areas
Keywords
- Actin, Propulsion, Stochastic simulation, Trajectory analysis