Non-Gaussian curvature distribution of actin-propelled biomimetic colloid trajectories

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Stephan Schmidt - , Universität Bayreuth (Autor:in)
  • Jasper Van Der Gucht - , Wageningen University & Research (WUR) (Autor:in)
  • P. Maarten Biesheuvel - , Max Planck Institute of Colloids and Interfaces (Autor:in)
  • Richard Weinkamer - , Max Planck Institute of Colloids and Interfaces (Autor:in)
  • Emmanuèle Helfer - , Centre national de la recherche scientifique (CNRS) (Autor:in)
  • Andreas Fery - , Universität Bayreuth (Autor:in)

Abstract

We analyze the motion of colloids propelled by a comet-like tail of polymerizing actin filaments. The curvature of the particle trajectories deviates strongly from a Gaussian distribution, implying that the underlying microscopic processes are fluctuating in a non-independent manner. Trajectories for beads of different size all showed the same non-Gaussian behavior, while the mean curvature decreased weakly with size. A stochastic simulation that includes nucleation, force-dependent dissociation, growth, and capping of filaments, shows that the non-Gaussian curvature distribution can be explained by a positive feedback mechanism in which attached chains under higher tension are more likely to snap.

Details

OriginalspracheEnglisch
Seiten (von - bis)1361-1366
Seitenumfang6
FachzeitschriftEuropean biophysics journal
Jahrgang37
Ausgabenummer8
PublikationsstatusVeröffentlicht - Okt. 2008
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

PubMed 18491086

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Actin, Propulsion, Stochastic simulation, Trajectory analysis