Myocardial uptake and biodistribution of newly designed technetium-labelled fatty acid analogues

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Anke C. Heintz - , Department of Anesthesiology and Intensive Care Medicine (Author)
  • Christian M. Jung - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Sebastian N. Stehr - , Department of Anesthesiology and Intensive Care Medicine (Author)
  • Peter Mirtschink - , Institute of Physiology (Author)
  • Martin Walther - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Jens Pietzsch - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Ralf Bergmann - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Hans Jürgen Pietzsch - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Hartmut Spies - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Gerd Wunderlich - , Department of Nuclear Medicine (Author)
  • Joachim Kropp - , Carl Thiem Clinics Cottbus (Author)
  • Andreas Deussen - , Institute of Physiology (Author)

Abstract

In an effort to develop 99mTc-labelled fatty acids (FAs) for myocardial metabolism and flow imaging, several 99mTc analogues according to the ‘3+1’ and the ‘4+1’ mixed-ligand approach were synthesized and myocardial extraction was evaluated in non-working isolated guinea pig hearts. An example of biodistribution patterns in guinea pigs was determined by using one FA analogue.

Details

Original languageEnglish
Pages (from-to)637-645
Number of pages9
JournalNuclear medicine communications
Volume28
Issue number8
Publication statusPublished - Aug 2007
Peer-reviewedYes

External IDs

PubMed 17625386

Keywords

ASJC Scopus subject areas

Keywords

  • Cardiac imaging, Coronary flow, Fatty acid derivatives, Myocardial tracer